| アブストラクト | BACKGROUND: To compare cumulative acute toxicity in head and neck cancer patients treated with concurrent chemoradiotherapy alone (CCRT) versus induction chemotherapy (IC) followed by CCRT (I/CCRT). METHODS: 77 patients underwent definitive CCRT (30 I/CCRT and 47 CCRT). Toxicity was graded using the Common Terminology Criteria for Adverse Events version 4.0. Using the TAME adverse event reporting system, short-term toxicity (T) scores were generated for IC (TIC), CCRT (TCCRT), total treatment duration (TRx), post-treatment period (TPT) and an overall score (Toverall) from treatment start to post treatment period. RESULTS: Acute toxicity other than dysphagia, odynophagia, or dermatitis was reported in 90.0% and 66.0% of I/CCRT and CCRT patients, respectively (P=0.02). Compared to CCRT group, I/CCRT patients reported greater mean TRx (TRx: 2.11 vs. 2.87, P=0.01) and Toverall (Toverall: 2.60 vs. 3.70, P=0.003). CONCLUSION: I/CCRT patients reported more cumulative acute toxicity during treatment compared to CCRT patients using the TAME reporting system. |
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| ジャーナル名 | American journal of otolaryngology |
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| Pubmed追加日 | 2017/04/22 |
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| 投稿者 | Shah, Bhartesh A; Qureshi, Muhammad M; Logue, Jennifer M; Cooley, Timothy P; Zaner, Ken S; Jalisi, Scharukh; Truong, Minh Tam |
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| 組織名 | Department of Radiation Oncology, Boston Medical Center, Boston University School;of Medicine, Boston, MA, United States.;Section of Hematology and Oncology, Department of Medicine, Boston Medical;Center, Boston University School of Medicine, Boston, MA, United States.;Department of Otolaryngology, Head and Neck Surgery, Boston Medical Center,;Boston University School of Medicine, Boston, MA, United States.;of Medicine, Boston, MA, United States. Electronic address: mitruong@bu.edu. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/28427799/ |
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