| アブストラクト | We have developed a Decision Support Environment (DSE) for medical experts at the US Food and Drug Administration (FDA). The DSE contains two integrated systems: The Event-based Text-mining of Health Electronic Records (ETHER) and the Pattern-based and Advanced Network Analyzer for Clinical Evaluation and Assessment (PANACEA). These systems assist medical experts in reviewing reports submitted to the Vaccine Adverse Event Reporting System (VAERS) and the FDA Adverse Event Reporting System (FAERS). In this manuscript, we describe the DSE architecture and key functionalities, and examine its potential contributions to the signal management process by focusing on four use cases: the identification of missing cases from a case series, the identification of duplicate case reports, retrieving cases for a case series analysis, and community detection for signal identification and characterization. |
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| ジャーナル名 | Journal of biomedical informatics |
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| 投稿日 | 2016/8/2 |
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| 投稿者 | Botsis, Taxiarchis; Jankosky, Christopher; Arya, Deepa; Kreimeyer, Kory; Foster, Matthew; Pandey, Abhishek; Wang, Wei; Zhang, Guangfan; Forshee, Richard; Goud, Ravi; Menschik, David; Walderhaug, Mark; Woo, Emily Jane; Scott, John |
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| 組織名 | Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and;Research, US Food and Drug Administration, United States. Electronic address:;Taxiarchis.Botsis@fda.hhs.gov.;Research, US Food and Drug Administration, United States.;Engility Corporation, United States. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/27477839/ |
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