| アブストラクト | PURPOSE: Pegloticase-associated adverse events reported to the Food and Drug Administration Adverse Event Reporting System (FAERS) database in the United States were evaluated. METHODS: Retrospective data-mining analysis of FAERS case reports listing Krystexxa or pegloticase as the suspect drug and specific adverse events (cardiovascular events, infusion-related reactions, gout flares, and anaphylaxis) was conducted from the drug's approval date (September 14, 2010) through August 27, 2012. Initial and follow-up reports with the same primary linked identification number were identified as unique to each patient case. When multiple reports for the same patient were identified with a common case number, the report with the most recent date was used to eliminate duplicate reports. Bayesian confidence propagation neural network methodology was used to identify signals of drug-associated adverse events. A potential signal for drug-adverse event reports is generated when the lower limit of the 95% two-sided confidence interval of the information component is greater than 0. RESULTS: A total of 118 unique cases of adverse events involving pegloticase in the United States were identified during the study period. Fourteen reports were related to pegloticase-associated cardiovascular events, and 35 were related to pegloticase-associated infusion-related reactions. Twenty-six reports were related to pegloticase-associated gout, and 11 were reports of pegloticase-associated anaphylaxis. Bayesian statistics identified potential signals for all pegloticase-associated adverse events (cardiovascular events, infusion reactions, gout flares, and anaphylaxis). CONCLUSION: Analysis of pegloticase-associated adverse events submitted to the FAERS database found that cardiovascular events, infusion-related reactions, gout flares, and anaphylaxis occurred more frequently than was statistically expected. |
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| ジャーナル名 | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists |
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| 投稿日 | 2014/4/16 |
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| 投稿者 | Gentry, William M; Dotson, Michael P; Williams, Brian S; Hartley, Melissa; Stafford, Kristen R; Bottorff, Michael B; Gandhi, Pranav K |
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| 組織名 | William M. Gentry, Pharm.D., is Assistant Professor and Executive Associate Dean;;Michael P. Dotson is Pharm.D. candidate; Brian S. Williams is Pharm.D. candidate;;Melissa Hartley is Pharm.D. candidate; Kristen R. Stafford is Pharm.D. candidate;;Michael B. Bottorff, Pharm.D., FCCP, CLS, is Professor and Chair of Pharmacy;Practice; and Pranav K. Gandhi, Ph.D., is Assistant Professor, Department of;Pharmacy Practice, School of Pharmacy, South College, Knoxville, TN. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/24733135/ |
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