| アブストラクト | BACKGROUND: We conducted the first study to investigate post-diagnostic oral bisphosphonates use and colorectal cancer-specific mortality. METHODS: Colorectal cancer patients were identified from the National Cancer Data Repository (1998-2007) and linked to the UK Clinical Practice Research Datalink, providing prescription records, and Office of National Statistics mortality data. Time-dependent Cox regression models investigated colorectal cancer-specific mortality in post-diagnostic bisphosphonate users. RESULTS: Overall, in 4791 colorectal cancer patients, there was no evidence of an association between bisphosphonate use and colorectal cancer-specific mortality (adjusted hazard ratio=1.11; 95% confidence interval 0.80, 1.54) or with drug frequency or type. CONCLUSIONS: In this novel population-based cohort study, post-diagnostic bisphosphonate use was not associated with longer rates of colorectal cancer survival. |
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| 組織名 | Cancer Epidemiology and Health Services Research Group, Centre for Public Health,;Queen's University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, Northern;Ireland, UK.;1] Cancer Epidemiology and Health Services Research Group, Centre for Public;Health, Queen's University Belfast, Royal Victoria Hospital, Belfast BT12 6BA,;Northern Ireland, UK [2] Centre of Excellence for Public Health (NI), Centre for;Public Health, Queen's University Belfast Royal Victoria Hospital, Belfast BT12;6BA, Northern Ireland, UK.;School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL,;Northern Ireland, UK. |
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