| アブストラクト | BACKGROUND: We estimated the multiple sclerosis (MS) incidence in the Netherlands for better active monitoring of potential vaccine safety signals. METHODS: A retrospective cohort study (1996-2008) was conducted using a population-based general practice research database containing electronic medical records. Additional information was collected to validate incident probable cases. RESULTS: In the source population (648,656 persons), 146 incident probable MS cases were identified. Overall incidence rate was 6.3/100,000 person years (py; 95% CI, 5.2-7.2). In the subgroup in which MS could be fully validated, the incidence increased from 4/100,000 py (95% CI, 3-5) in 1996-2004 to 9/100,000 py in 2007/8 (95% CI, 6-16). This increase was highest among women, but not statistically significantly different by gender. The median lag time between first recorded symptoms and MS diagnosis decreased from 32 months (<1998) to 2 months (>2005). CONCLUSIONS: MS is rare in the Netherlands. In recent years, there was a slight increase in the incidence especially among women during the fertile age. This increase coincided with a decrease in lag time between symptoms and diagnosis, both for men and women. This trend should be taken into account in the interpretation of MS cases occurring in a population where new vaccinations will be introduced shortly. |
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| ジャーナル名 | Neuroepidemiology |
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| Pubmed追加日 | 2012/07/21 |
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| 投稿者 | Kramer, M A; van der Maas, N A T; van Soest, E M; Kemmeren, J M; de Melker, H E; Sturkenboom, M C J M |
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| 組織名 | Department of Epidemiology and Surveillance, Center for Infectious Disease;Control, National Institute for Public Health and the Environment, Bilthoven, The;Netherlands. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/22814194/ |
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