| アブストラクト | BACKGROUND: Oestrogen and progestogen have the potential to influence gastro-intestinal motility; both are key components of hormone replacement therapy (HRT). Results of observational studies in women taking HRT rely on self-reporting of gastro-oesophageal symptoms and the aetiology of gastro-oesophageal reflux disease (GORD) remains unclear. This study investigated the association between HRT and GORD in menopausal women using validated general practice records. METHODS: 51,182 menopausal women were identified using the UK General Practice Research Database between 1995-2004. Of these, 8,831 were matched with and without hormone use. Odds ratios (ORs) were calculated for GORD and proton-pump inhibitor (PPI) use in hormone and non-hormone users, adjusting for age, co-morbidities, and co-pharmacy. RESULTS: In unadjusted analysis, all forms of hormone use (oestrogen-only, tibolone, combined HRT and progestogen) were statistically significantly associated with GORD. In adjusted models, this association remained statistically significant for oestrogen-only treatment (OR 1.49; 1.18-1.89). Unadjusted analysis showed a statistically significant association between PPI use and oestrogen-only and combined HRT treatment. When adjusted for covariates, oestrogen-only treatment was significant (OR 1.34; 95% CI 1.03-1.74). Findings from the adjusted model demonstrated the greater use of PPI by progestogen users (OR 1.50; 1.01-2.22). CONCLUSIONS: This first large cohort study of the association between GORD and HRT found a statistically significant association between oestrogen-only hormone and GORD and PPI use. This should be further investigated using prospective follow-up to validate the strength of association and describe its clinical significance. |
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| ジャーナル名 | BMC gastroenterology |
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| Pubmed追加日 | 2012/5/31 |
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| 投稿者 | Close, Helen; Mason, James M; Wilson, Douglas; Hungin, A Pali S |
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| 組織名 | Durham Clinical Trials Unit, Queen's Campus, Wolfson Research Institute,;University of Durham, University Boulevard, Stockton-on-Tees, TS17 6BH, UK.;h.j.close@durham.ac.uk |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/22642788/ |
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