| アブストラクト | BACKGROUND: Outbreak reports suggest that community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections can be life-threatening. We conducted a population based cohort study to assess the magnitude of mortality associated with MRSA infections diagnosed in the community. METHODS: We used the United Kingdom's General Practice Research Database (GPRD) to form a cohort of all patients with MRSA diagnosed in the community from 2001 through 2004 and up to ten patients without an MRSA diagnosis. The latter were frequency-matched with the MRSA patients on age, GPRD practice and diagnosis date. All patients were older than 18 years, had no hospitalization in the 2 years prior to cohort entry and medical history information of at least 2 years prior to cohort entry. The cohort was followed up for 1 year and all deaths and hospitalizations were identified. Hazard ratios of all-cause mortality were estimated using the Cox proportional hazards model adjusted for patient characteristics. RESULTS: The cohort included 1439 patients diagnosed with MRSA and 14,090 patients with no MRSA diagnosis. Mean age at cohort entry was 70 years in both groups, while co-morbid conditions were more prevalent in the patients with MRSA. Within 1 year, 21.8% of MRSA patients died as compared with 5.0% of non-MRSA patients. The risk of death was increased in patients diagnosed with MRSA in the community (adjusted hazard ratio 4.1; 95% confidence interval: 3.5-4.7). CONCLUSION: MRSA infections diagnosed in the community are associated with significant mortality in the year after diagnosis. |
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| ジャーナル名 | BMC medicine |
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| Pubmed追加日 | 2008/2/1 |
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| 投稿者 | Delaney, J A 'Chris'; Schneider-Lindner, Verena; Brassard, Paul; Suissa, Samy |
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| 組織名 | Division of Clinical Epidemiology, McGill University Health Center, Royal;Victoria Hospital, 687 Pine Avenue West, Ross 4,29, Montreal, H3A 1A1, Canada.;joseph.delaney@mail.mcgill.ca |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/18234115/ |
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