| アブストラクト | BACKGROUND: Irritable bowel syndrome is a common problem known to have a complex relationship with psychological disorders and other physical symptoms. Little information, however, is available concerning physical and psychological comorbidity in irritable bowel syndrome patients studied over an extended period. AIM: To evaluate physical and psychological morbidity 2 years before and during 6 years after the time of diagnosis in incident cases of irritable bowel syndrome and control subjects. METHODS: A matched cohort study was implemented in 123 general practices using the General Practice Research Database. Irritable bowel syndrome cases (n = 1827) and controls (n = 3654) were compared for 2 years before and 6 years after diagnosis. RESULTS: The age-standardized incidence of irritable bowel syndrome in patients over 15 years of age was 1.9 per 1,000 in men and 5.8 per 1,000 in women. From 2 years before the date of diagnosis, more irritable bowel syndrome cases (13%) than controls (5%) consulted with depression or were prescribed antidepressant drugs. Consultation and prescription rates for anxiety were also higher before diagnosis, and both anxiety and depression remained prevalent up to 6 years after diagnosis. Asthma, symptoms of urinary tract infection, gall-bladder surgery, hysterectomy and diverticular disease were recorded more frequently in irritable bowel syndrome patients, who were also more likely than controls to be referred to hospital. CONCLUSIONS: People who are diagnosed with irritable bowel syndrome experience more anxiety and depression and a range of physical problems, compared with controls; they are more likely to be referred to hospital. |
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| ジャーナル名 | Alimentary pharmacology & therapeutics |
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| Pubmed追加日 | 2006/8/22 |
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| 投稿者 | Jones, R; Latinovic, R; Charlton, J; Gulliford, M |
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| 組織名 | Division of Health and Social Care Research, King's College London School of;Medicine, London, UK. roger.jones@kcl.ac.uk |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/16918893/ |
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