| アブストラクト | AIM: To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol. METHODS: Observational cohort study of thioridazine and haloperidol users in the UK General Practice Research Database (GPRD) using data from 1987 through 29 June 2000. Patients were followed for 30 days following each study prescription. The event of interest was a diagnosis of ventricular arrhythmia, sudden death, or unexplained or unattended death. Cox regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs), to examine potential confounding factors, and to examine dose-response relationships. RESULTS: Use of thioridazine and haloperidol in the GPRD was primarily in older patients, at low dose (median daily dose 31 mg thioridazine, 1.8 mg haloperidol). There was no association between thioridazine use and the rate of ventricular arrhythmia, sudden death, and unexplained or unattended death (adjusted RR 0.9, 95% CI 0.7, 1.1). The rate did not appear to increase with dose for either drug over the range observed. CONCLUSIONS: These results suggest that low-dose thioridazine and haloperidol have similar cardiac safety. |
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| ジャーナル名 | British journal of clinical pharmacology |
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| Pubmed追加日 | 2004/06/23 |
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| 投稿者 | Hennessy, Sean; Bilker, Warren B; Knauss, Jill S; Kimmel, Stephen E; Margolis, David J; Morrison, Mary F; Reynolds, Robert F; Glasser, Dale B; Strom, Brian L |
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| 組織名 | Center for Clinical Epidemiology & Biostatistics, Department of Biostatistics &;Epidemiology, and Center for Education & Research in Therapeutics, University of;Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.;shenness@cceb.med.upenn.edu |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/15206997/ |
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