| アブストラクト | BACKGROUND: The contents of the guidelines for the use of non-benzodiazepines (Z-drugs) differ slightly between THE JAPANESE SOCIETY OF SLEEP RESEARCH and THE JAPAN GERIATRIC SOCIETY, and the recommended directions are conflicting. Therefore, we analyzed the use of the Japanese Adverse Drug Event Report database (JADER) for identifying adverse events (AEs) caused by Z-drugs and clarifying their occurrence trend and prognosis. METHODS: The signal value for comparison was calculated by using the proportional reporting ratio (PRR) and chi-squared test (chi(2)) results of data of elderly and non-elderly patients. Among AEs for which signals were detected in the elderly, we determined that those with lower signal values for non-elderly patients that were half the signal value of the elderly should be used with particular caution in the elderly. We also compared the prognoses. RESULTS: The AEs with > 1 risk ratio (RR) in elderly and non-elderly patients were regarded as those that should be noted in the prognosis of AEs in elderly patients. Furthermore, 28 AEs were detected in elderly patients' signals. In this study, in addition to movement disorders such as "falls" and "bone fractures," identified by two academic societies, signal characteristics of the elderly were obtained for psychiatric disorders and eye disorders. CONCLUSIONS: There was no difference in prognosis, but these disorders could reduce the quality of life of patients. Therefore, we consider that in prescribing appropriate drug therapy for insomnia, attention should be paid to the occurrence of the AEs caused by the Z-drugs revealed by this study and the guidelines. |
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| ジャーナル名 | Journal of pharmaceutical health care and sciences |
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| Pubmed追加日 | 2018/5/16 |
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| 投稿者 | Noguchi, Yoshihiro; Ueno, Anri; Katsuno, Hayato; Otsubo, Manami; Yoshida, Aki; Kanematsu, Yuta; Sugita, Ikuto; Tachi, Tomoya; Tsuchiya, Teruo; Teramachi, Hitomi |
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| 組織名 | 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4,;Daigakunishi, Gifu, 501-1196 Japan.0000 0000 9242 8418grid.411697.c;Community Health Support and Research Center, 5-6-1, kikuchichou, Gifu, 501-6242;Japan.;3Laboratory of Community Healthcare Pharmacy, Gifu Pharmaceutical University,;1-25-4, Daigakunishi, Gifu, 501-1196 Japan.0000 0000 9242 8418grid.411697.c |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/29760940/ |
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