| アブストラクト | Elevated levels of prenatal testosterone may increase the risk for autism spectrum conditions (autism). Given that polycystic ovary syndrome (PCOS) is also associated with elevated prenatal testosterone and its precursor sex steroids, a hypothesis from the prenatal sex steroid theory is that women with PCOS should have elevated autistic traits and a higher rate of autism among their children. Using electronic health records obtained from the Clinical Practice Research Datalink (CPRD) in the UK between 1990 and 2014, we conducted three matched case-control studies. Studies 1 and 2 examined the risk of PCOS in women with autism (n = 971) and the risk of autism in women with PCOS (n = 26,263), respectively, compared with matched controls. Study 3 examined the odds ratio (OR) of autism in first-born children of women with PCOS (n = 8588), matched to 41,127 controls. In Studies 1 and 2 we found increased prevalence of PCOS in women with autism (2.3% vs. 1.1%; unadjusted OR: 2.01, 95% CI: 1.22-3.30) and elevated rates of autism in women with PCOS (0.17% vs. 0.09%, unadjusted OR: 1.94 CI: 1.37-2.76). In Study 3 we found the odds of having a child with autism were significantly increased, even after adjustment for maternal psychiatric diagnoses, obstetric complications, and maternal metabolic conditions (unadjusted OR: 1.60, 95% CI: 1.28-2.00; adjusted OR: 1.35, 95% CI: 1.06-1.73). These studies provide further evidence that women with PCOS and their children have a greater risk of autism. |
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| 組織名 | Autism Research Centre, Department of Psychiatry, University of Cambridge,;Douglas House, 18B Trumpington Road, Cambridge, CB2 8AH, UK.;adriana.cherskov@yale.edu.;Department of Biostatistics, Yale University School of Public Health, New Haven,;CT, 06520, USA.;Primary Care Unit, Institute of Public Health, University of Cambridge,;Cambridge, CB2 OSR, UK.;Centre for Academic Primary Care, Bristol Medical School, University of Bristol,;Bristol, BS8 2PS, UK.;Douglas House, 18B Trumpington Road, Cambridge, CB2 8AH, UK. sb205@cam.ac.uk.;CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge,;UK. sb205@cam.ac.uk. |
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