| アブストラクト | BACKGROUND: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Reports on differences in reporting patterns between women and men exist nationally. The goal of the present study was to assess the global evidence on spontaneous post-marketing ADR reporting differences between reports for women and men. METHODS: We analysed data collected within VigiBase, the WHO global database of individual case safety reports, between 1967-2 January 2018. VigiBase contains more than 18 million reports from the 131 member countries of the WHO Programme for International Drug Monitoring. FINDINGS: Of the reports with information on sex, 9,056,566 (60.1%) concerned female and 6,012,804 (39.9%) male children and adults. More female ADR reports were submitted in all regions of the world and by all types of reporters. A higher proportion of female reports was seen in all age groups from the age group 12-17 years and older. The largest difference was observed in the age group of 18-44 years and could not be explained by hormonal contraceptive use. The proportion of serious and fatal reports was higher for male reports. INTERPRETATION: Global post marketing surveillance data on spontaneous reports indicate that women, from puberty and onwards and especially in their reproductive years, report more ADRs than men. However, there is a higher proportion of serious and fatal ADRs among male reports. Our results suggest important underlying sex-related differences in ADRs. These findings highlight the importance of considering sex throughout the entire life-cycle of drug development and surveillance and understanding the underlying reasons for reporting ADRs. |
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| ジャーナル名 | EClinicalMedicine |
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| Pubmed追加日 | 2020/1/1 |
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| 投稿者 | Watson, Sarah; Caster, Ola; Rochon, Paula A; den Ruijter, Hester |
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| 組織名 | Uppsala Monitoring Centre, Box 1050, Uppsala S-751 40, Sweden.;Department of Medicine and Institute of Health Policy, Management and Evaluation,;University of Toronto. Women's College Research Institute, Women's College;Hospital, 76 Grenville Street, Toronto, Ontario M5S 1B2, Canada.;Laboratory of Experimental Cardiology, University Medical Center Utrecht,;University of Utrecht, Heidelberglaan 100, Utrecht 3584 CX, the Netherlands. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/31891132/ |
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