| アブストラクト | PURPOSE: The Clinical Practice Research Datalink (CPRD) now provides a new medical record database, CPRD Aurum. This is the first of several studies being undertaken to assess the quality and completeness of CPRD Aurum data for research endeavors. METHODS: We identified patients with a pulmonary embolism (PE) diagnosis from a random sample of 50 000 patients in CPRD Aurum and compared the diagnoses using data from Hospital Episode Statistics (HES). We calculated the proportion of PE cases recorded in CPRD Aurum who also had a PE diagnosis recorded in HES. We also evaluated completeness by identifying all PE diagnoses in HES and calculating the proportion also present in CPRD Aurum. RESULTS: The study included 781 PE patients: 580 had a PE in CPRD Aurum, 632 had a PE in HES, and 431 had a PE in both. The proportion of patients with anticoagulated PE in CPRD Aurum confirmed by HES was 76.8%. The completeness of primary hospitalized PE HES events compared to CPRD Aurum was 79.1%. In most instances, there was a plausible explanation for the presence of a PE in only one of the two data sources. CONCLUSIONS: The results of this study are reassuring and suggest that the correctness (eg, quality, accuracy) and completeness of diagnosis information in CPRD Aurum are promising with respect to serious acute conditions that require medical attention. Evaluation of other data elements will provide additional insight into this new data resource and its utility for medical research. |
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| ジャーナル名 | Pharmacoepidemiology and drug safety |
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| 投稿日 | 2020/3/30 |
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| 投稿者 | Jick, Susan S; Hagberg, Katrina Wilcox; Persson, Rebecca; Vasilakis-Scaramozza, Catherine; Williams, Tim; Crellin, Elizabeth; Myles, Puja |
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| 組織名 | Boston Collaborative Drug Surveillance Program, Lexington, MA, USA.;Boston University School of Public Health, Boston, MA, USA.;Clinical Practice Research Datalink, Medicines and Healthcare Products Regulatory;Agency, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32222005/ |
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