| アブストラクト | Pitch perception modifications are among the little-known adverse effects observed with antiepileptics, mainly affecting patients treated with carbamazepine (CBZ). Here, we describe an original French case of pitch perception modification due to CBZ resulting in perfect pitch loss. We also reviewed the literature as well as French and world health organisation global pharmacovigilance database. The case report concerns a 22-year-old patient with perfect pitch with untreated left temporal partial epilepsy. Following a generalized seizure, the introduction of CBZ prolonged release (200mg twice a day) is decided. As soon as CBZ is introduced, the patient notices a change in pitch perception, about a semitone lower. This adverse effect persisted despite a gradual decrease in doses. The patient reported a total recovery of his perfect pitch when CBZ stopped completely 11 years later. In the French pharmacovigilance database, only one other case of pitch perception modification under CBZ was recorded (no cases were found with oxcarbazepine, lacosamide, sodium valproate, lamotrigine, levetiracetam, phenobarbital, phenytoin, primidone, ethosuximide, vigabatrine, felbamate, gabapentin, tiagabine and topiramate). In the literature, 27 cases of pitch perception modification have been published with CBZ, 1 case with oxcarbazepine and 1 case with lacosamide. Pitch perception modification is a very rare adverse effect of CBZ, oxcarbazepine and lacosamide, identified in the literature mainly in the Japanese population, in experienced musicians. A rapid onset after the introduction of treatment, a complete resolution of symptoms, in most cases upon discontinuation of treatment, is observed, with no sequelae reported. Due to the impact on quality of life, especially in patients whose profession is related to music, knowledge of this adverse event seems important to evoke this diagnosis. |
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| ジャーナル名 | Therapie |
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| Pubmed追加日 | 2020/3/25 |
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| 投稿者 | Le Dare, Brendan; Triquet, Louise; Degremont, Adeline; Charbonnel, Hoel; Default, Anne; Osmont, Marie-Noelle; Picard, Sylvie; Gentilhomme, Guillaume; Bellissant, Eric; Scailteux, Lucie-Marie; Polard, Elisabeth |
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| 組織名 | Centre regional de pharmacovigilance, pharmacoepidemiologie et information sur le;medicament, hopital universitaire de Rennes, CHU de Rennes, 2, rue Henri-Le;Guilloux, 35000 Rennes, France. Electronic address:;brendan.le.dare@chu-rennes.fr.;Guilloux, 35000 Rennes, France.;Medecin generaliste liberal, 35000 Rennes, France.;Centre regional de pharmacovigilance Marseille-Provence-Corse, hopital;Sainte-Marguerite, Assistance publique-Hopitaux de Marseille, 130005 Marseille,;France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32204934/ |
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