| アブストラクト | OBJECTIVE: Our aim was to characterize Adverse Drug Reactions (ADRs) related to drug-drug interactions (DDIs) related to involvement of cytochrome P450 (CYP450) isoenzymes in a pharmacovigilance database. METHODS: ADRs recorded by Midi-Pyrenees PharmacoVigilance center (France) between 1 January and 31 August 2008 were extracted from the French PharmacoVigilance Database (FPVD). RESULTS: Among the 1,205 reported ADRs, 16 (1.3 %), can be explained by involvement of CYP450 isoenzymes (including 4 "serious"). All interactions involved CYP inhibitors, mainly for CYP3A4/5. CONCLUSION: The percentage of ADRs reported in the pharmacovigilance database and related to CYP450-induced DDIs appears to be relatively low (~ 1-2 %). |
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| ジャーナル名 | European journal of clinical pharmacology |
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| Pubmed追加日 | 2012/9/22 |
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| 投稿者 | Danton, Anne Charlotte; Montastruc, Francois; Sommet, Agnes; Durrieu, Genevieve; Bagheri, Haleh; Bondon-Guitton, Emmanuelle; Lapeyre-Mestre, Maryse; Montastruc, Jean-Louis |
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| 組織名 | Service de Pharmacologie Clinique, Centre Midi-Pyrenees de Pharmacovigilance, de;Pharmacoepidemiologie et d'Informations sur le Medicament, Centre Hospitalier;Universitaire de Toulouse, Toulouse, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/22996074/ |
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