| アブストラクト | PURPOSE: Beta-lactams (BL), the most commonly prescribed class of antibiotics, are recommended as the first-line therapy for multiple indications in infectious disease guidelines. Meropenem (MERO) is frequently used in intensive care units (ICU) to treat bacterial infections with or without sepsis. The pharmacokinetics of MERO display a large variability in patients admitted to ICUs due to altered pathophysiology. The aim of this study was to perform an external evaluation of published population pharmacokinetic models of MERO in order to test their predictive performance in a cohort of ICU adult patients. METHODS: A literature search in PubMed/Medline database was made following the PRISMA statement. External evaluation was performed using NONMEM software, and the bias and inaccuracy values were calculated. RESULTS: An external validation dataset from the Timone Hospital in Marseille, France, included 84 concentration samples from 27 patients. Four models of MERO were identified according to the inclusion criteria of the study. None of the models presented acceptable values of bias and inaccuracy. CONCLUSION: While performing external evaluations on some populations may confirm a model's suitability to diverse groups of patients, there is still some variability that cannot be explained nor solved by the procedure. This brings to light the difficulty to develop only one model for ICU patients and the need to develop one specific model to each population of critically ill patients. |
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| 組織名 | Laboratoire de Suivi Therapeutique Pharmacologique et Pharmacocinetique, Faculte;de Pharmacie, Universite de Montreal, Pavillon Jean-Coutu, 2940 chemin de;Polytechnique, Montreal, QC, H3T 1J4, Canada.;Faculte de Pharmacie, Universite de Montreal, Montreal, QC, Canada.;Service de Pharmacologie Clinique et Pharmacovigilance, Hopital de la Timone,;Assistance Publique des Hopitaux de Marseille, Marseille, France.;Pharmacologie integree et interface clinique et industrielle, Institut de;Neuroscience des systemes, CNRS 7289, Aix Marseille Universite, 13385, Marseille,;France.;Service d'Anesthesie-Reanimation, Hopital de la Timone, Assistance Publique des;Hopitaux de Marseille, Marseille, France.;Polytechnique, Montreal, QC, H3T 1J4, Canada. amelie.marsot@umontreal.ca.;amelie.marsot@umontreal.ca.;Centre de Recherche, CHU Sainte Justine, Montreal, QC, Canada. |
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