| アブストラクト | BACKGROUND: Anorexia nervosa is characterized by a severe restriction of caloric intake, low body weight, fear of gaining weight or of becoming fat, and disturbance of body image. Pathogenesis of the disorder may include genetic predisposition, hormonal changes and a combination of environmental, psychosocial, and cultural factors. Cancer is the second leading cause of death worldwide. At present, no systematic reviews and meta-analyses have evaluated the risk of cancer in people with anorexia nervosa. The objective of this study will be to evaluate the association between anorexia nervosa and the risk of developing or dying from cancer. METHODS/DESIGN: This study protocol is part of a systematic collection and assessment of multiple systematic reviews and meta-analyses (umbrella review) evaluating the association of cancer and multiple central nervous system disorders. We designed a specific protocol for a new systematic review and meta-analysis of observational studies of anorexia nervosa with risk of developing or dying from any cancer. Data sources will be PubMed, Embase, Scopus, Web of Science, and manual screening of references. Observational studies (case-control and cohort) in humans that examined the association between anorexia nervosa and risk of developing or dying from cancer will be sought. The primary outcomes will be cancer incidence and cancer mortality in association with anorexia nervosa. Secondary outcomes will be site-specific cancer incidence and mortality, respectively. Screening of abstracts and full texts, and data abstraction will be performed by two team members independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. The quality of studies will be assessed by using the Ottawa-Newcastle scale by two team members independently. Random effects models will be conducted where appropriate. Subgroup and additional analyses will be conducted to explore the potential sources of heterogeneity. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) criteria and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used for determining the quality of evidence for cancer outcomes. DISCUSSION: Findings from this systematic review will inform an ongoing umbrella review on cancer and central nervous system disorders. Our systematic review and meta-analysis of observational studies will establish the extent of the epidemiological evidence underlying the association between anorexia nervosa and cancer. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017067462. |
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| 投稿者 | Catala-Lopez, Ferran; Hutton, Brian; Driver, Jane A; Ridao, Manuel; Valderas, Jose M; Genova-Maleras, Ricard; Fores-Martos, Jaume; Alonso-Arroyo, Adolfo; Saint-Gerons, Diego Macias; Vieta, Eduard; Valencia, Alfonso; Tabares-Seisdedos, Rafael |
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| 組織名 | Department of Medicine, University of Valencia/INCLIVA Health Research Institute;and CIBERSAM, Valencia, Spain. ferran_catala@hotmail.com.;Fundacion Instituto de Investigacion en Servicios de Salud, Valencia, Spain.;ferran_catala@hotmail.com.;Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa,;Ontario, Canada. ferran_catala@hotmail.com.;Ontario, Canada.;School of Epidemiology, Public Health and Preventive Medicine, University of;Ottawa, Ottawa, Ontario, Canada.;Geriatric Research Education and Clinical Center, VA Boston Healthcare System,;Boston, MA, USA.;Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard;Medical School, Boston, MA, USA.;Instituto Aragones de Ciencias de la Salud, Red de Investigacion en Servicios de;Salud en Enfermedades Cronicas (REDISSEC), Zaragoza, Spain.;Fundacion para el Fomento de la Investigacion Sanitaria y Biomedica de la;Comunitat Valenciana (FISABIO-Salud Publica), Valencia, Spain.;Health Services and Policy Research Group, Exeter Collaboration for Academic;Primary Care, University of Exeter Medical School, University of Exeter, Exeter,;UK.;Directorate General for Public Health, Regional Health Council, Madrid, Spain.;and CIBERSAM, Valencia, Spain.;Department of History of Science and Documentation, University of Valencia,;Valencia, Spain.;Unidad de Informacion e Investigacion Social y Sanitaria-UISYS, University of;Valencia-Spanish National Research Council (CSIC), Valencia, Spain.;Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines and;Healthcare Products Agency, Madrid, Spain.;Department of Health Systems and Services, Unit of Medicines and Health;Technologies, Pan American Health Organization, Washington, DC, USA.;Hospital Clinic, Universitat de Barcelona, Institut d'Investigacions Biomediques;August Pi i Sunyer (IDIBAPS) and CIBERSAM, Barcelona, Spain.;Life Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain.;Structural Biology and Biocomputing Programme, Spanish National Cancer Research;Centre (CNIO), Madrid, Spain. |
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