Intestinal obstruction in pregnancy by ondansetron.

アブストラクト	BACKGROUND: Ondansetron use for nausea and vomiting during pregnancy has increased in the last years, although its maternal and fetal safety is not conclusive. CASE: We describe a case of intestinal obstruction in a pregnant woman with severe nausea and vomiting of pregnancy treated with ondansetron, which is known to slow gut motility. CONCLUSION: The spontaneous reporting system of WHO confirms that this potentially life threatening complication is more common than what the peer review literature may suggest and needs to be looked into carefully, especially in view of the wide spread off-label use for NVP.
ジャーナル名	Reproductive toxicology (Elmsford, N.Y.)
Pubmed追加日	2014/12/3
投稿者	Cohen, Rana; Shlomo, Meital; Dil, Dorit Nahlieli; Dinavitser, Natalia; Berkovitch, Mati; Koren, Gideon
組織名	Motherisk Israel, Unit of Clinical Pharmacology, Assaf Harofeh Medical Center,;Zerifin, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.;Electronic address: meitalym42@gmail.com.;Pharmaceutical Division, Ministry of Health, Israel.;Zerifin, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; The;Motherisk Program, Division of Clinical Pharmacology-Toxicology, Department of;Pediatrics, The Hospital for Sick Children and The University of Toronto,;Toronto, Canada. Electronic address: gkoren@sickkids.ca.
Pubmed リンク	https://www.ncbi.nlm.nih.gov/pubmed/25461913/