| アブストラクト | BACKGROUND AND AIMS: Using a nationwide epidemiological database, we aimed to clarify the association of fasting plasma glucose (FPG) with subsequent cardiovascular disease (CVD) risk among young adults. METHODS AND RESULTS: Medical records of 1,180,062 young adults (20-49 years old) without a prior history of CVD and who were not taking antidiabetic medications were extracted from the Japan Medical Data Center. We categorized the study population into four groups: normal, FPG level<100 mg/dL (1,007,747 individuals), normal-high, FPG level of 100-109 mg/dL (126,602 individuals), impaired fasting glucose (IFG), FPG level of 110-125 mg/dL (32,451 individuals), and diabetes mellitus (DM), FPG level >/=126 mg/dL (13,262 individuals). The mean age was 39.7 +/- 6.9 years, and 57.0% of the study population were men. Mean follow-up period was 1201 +/- 905 days on average. Multivariable Cox regression analysis showed that IFG (hazard ratio [HR]; 1.38) and DM (HR; 2.09) increased the risk of myocardial infarction. Normal-high (HR; 1.11), IFG (HR; 1.18), and DM (HR; 1.59) groups had an elevated angina pectoris risk. DM (HR; 1.31) increased the risk of stroke compared to normal FPG levels. Normal-high levels (HR; 1.10), IFG (HR; 1.22) and DM (HR; 1.58) elevated the risk of heart failure. DM (HR; 1.69) increased the risk of atrial fibrillation. CONCLUSIONS: Our analysis of a nationwide epidemiological database demonstrated a close association of the FPG category with subsequent CVD risk. Our results exemplify the importance of optimal FPG maintenance for the primary prevention of CVD in young adults. |
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| ジャーナル名 | Atherosclerosis |
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| Pubmed追加日 | 2021/1/20 |
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| 投稿者 | Kaneko, Hidehiro; Itoh, Hidetaka; Kiriyama, Hiroyuki; Kamon, Tatsuya; Fujiu, Katsuhito; Morita, Kojiro; Michihata, Nobuaki; Jo, Taisuke; Takeda, Norifumi; Morita, Hiroyuki; Yasunaga, Hideo; Komuro, Issei |
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| 組織名 | The Department of Cardiovascular Medicine, The University of Tokyo, Japan; The;Department of Advanced Cardiology, The University of Tokyo, Japan. Electronic;address: hidehikaneko-circ@umin.ac.jp.;The Department of Cardiovascular Medicine, The University of Tokyo, Japan.;Department of Advanced Cardiology, The University of Tokyo, Japan.;The Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, Japan; The Department of Health Services;Research, Faculty of Medicine, University of Tsukuba, Japan.;The Department of Health Services Research, The University of Tokyo, Japan.;Health, The University of Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33465660/ |
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