| アブストラクト | Acute generalized exanthematous pustulosis (AGEP) is a rare skin adverse drug reaction. The pathophysiology and causative drugs associated with AGEP are poorly understood, with the majority of studies in AGEP focusing on a single-drug-outcome association. We therefore aimed to explore and characterize frequently reported drug combinations associated with AGEP using the WHO pharmacovigilance database VigiBase. In this explorative cross-sectional study of a pharmacovigilance database using a data-driven approach, we assessed individual case safety reports (ICSR) with two or more drugs reported to VigiBase. A total of 2649 ICSRs reported two or more drugs. Cardiovascular drugs, including antithrombotics and beta-blockers, were frequently reported in combination with other drugs, particularly antibiotics. The drug pair of amoxicillin and furosemide was reported in 57 ICSRs (2.2%), with an O/E ratio of 1.3, and the combination of bisoprolol and furosemide was recorded 44 times (1.7%), with an O/E ratio of 5.5. The network analysis identified 10 different communities of varying sizes. The largest cluster primarily consisted of cardiovascular drugs. This data-driven and exploratory study provides the largest real-world assessment of drugs associated with AGEP to date. The results identify a high frequency of cardiovascular drugs, particularly used in combination with antibiotics. |
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| ジャーナル名 | Journal of clinical medicine |
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| Pubmed追加日 | 2021/10/14 |
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| 投稿者 | Martinez-De la Torre, Adrian; van Weenen, Eva; Kraus, Mathias; Weiler, Stefan; Feuerriegel, Stefan; Burden, Andrea M |
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| 組織名 | Institute of Pharmaceutical Sciences, Department of Chemistry and Applied;Biosciences, ETH Zurich, 8093 Zurich, Switzerland.;Management Information Systems, Department of Management, Technology and;Economics, ETH Zurich, 8092 Zurich, Switzerland. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34640505/ |
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