| アブストラクト | Aim: To compare blood pressure (BP) and safety outcomes in patients with hypertension initiating bisoprolol, versus other beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, calcium channel blockers or diuretics. Materials & methods: New user cohort study. Patients initiating bisoprolol were matched with up to four patients, in each comparator cohort using propensity score. BP outcomes were compared using linear mixed models and safety outcomes using Cox proportional hazards. Results: Differences in average systolic and diastolic BP variation were </=3 mmHg between bisoprolol versus the compared classes. No difference was observed in risk of diabetes, obesity or erectile dysfunction. An increased dyslipidemia risk was only observed versus diuretics (hazard ratio: 0.76; 98.75% CI: 0.58, 0.99). Conclusion: No differences in BP variation and safety outcomes. |
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| ジャーナル名 | Journal of comparative effectiveness research |
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| Pubmed追加日 | 2022/2/23 |
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| 投稿者 | Foch, Caroline; Allignol, Arthur; Hohenberger, Thilo; Boutmy, Emmanuelle; Schaefer, Stephan; Hostalek, Ulrike |
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| 組織名 | Merck KGaA, Frankfurter Str 250, Darmstadt, 64293, Germany. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35189710/ |
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