| アブストラクト | BACKGROUND: Perinatal self-harm is of concern but poorly understood. AIMS: To determine if women's risk of self-harm changes in pregnancy and the first postpartum year, and if risk varies by mental illness, age and birth outcome. METHOD: This was a retrospective cohort study of 2 666 088 women aged 15-45 years from the 1 January 1990 to 31 December 2017 linked to 1 102 040 pregnancies and their outcomes, utilising the Clinical Practice Research Datalink and Pregnancy Register. We identified self-harm events and mental illness (depression/anxiety/addiction/affective/non-affective psychosis/eating/personality disorders) from clinical records and grouped women's age into 5-year bands. They calculated the rate of self-harm during discrete non-perinatal, pregnant and postpartum periods. We used a gap-time, stratified Cox model to manage multiple self-harm events, and calculated the unadjusted and adjusted hazard ratios (adjHR) of self-harm associated with pregnancy and the postpartum compared with non-perinatal periods. Pre-planned interactions tested if risk varied by mental illness, age and birth outcome. RESULTS: The analysis included 57 791 self-harm events and 14 712 319 person-years of follow-up. The risk of self-harm shrank in pregnancy (2.07 v. 4.01 events/1000 person-years, adjHR = 0.53, 95% CI 0.49-0.58) for all women except for 15- to 19-year-olds (adjHR = 0.95, 95% CI 0.84-1.07) and the risk reduced most for women with mental illness (adjHR = 0.40, 95% CI 0.36-0.44). Postpartum, self-harm risk peaked at 6-12 months (adjHR = 1.08, 95% CI 1.02-1.15), at-risk groups included young women and women with a pregnancy loss or termination. CONCLUSIONS: Maternity and perinatal mental health services are valuable. Family planning services might have psychological benefit, particularly for young women. |
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| ジャーナル名 | The British journal of psychiatry : the journal of mental science |
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| Pubmed追加日 | 2022/3/2 |
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| 投稿者 | Hope, Holly; Pierce, Matthias; Osam, Cemre Su; Morgan, Catharine; John, Ann; Abel, Kathryn M |
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| 組織名 | Centre for Women's Mental Health, Division of Psychology and Mental Health,;Faculty of Biology, Medicine and Health, University of Manchester, UK.;Division of Population Health, Health Services Research & Primary Care, Faculty;of Biology, Medicine and Health, University of Manchester, UK.;Swansea University Medical School, Swansea University, UK.;Faculty of Biology, Medicine and Health, University of Manchester, UK and Greater;Manchester Mental Health NHS Foundation Trust, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35227334/ |
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