| アブストラクト | OBJECTIVES: To identify potential confounders and co-interventions systematically to optimise control of confounding for three non-randomized studies of interventions (NRSI) designed to quantify bleeding in populations exposed to different dual antiplatelet therapy (DAPT). STUDY DESIGN AND SETTING: Systematic review, interviews, and surveys with clinicians. We searched Ovid Medline, Ovid Embase, and the Cochrane Library to identify randomized-controlled trials and cohort studies of DAPT interventions. Two researchers independently screened citations, identified eligible studies and extracted data. We conducted individual semi-structured interviews with six cardiologists and six cardiac surgeons to elicit factors clinicians consider when they prescribe DAPT. We administered two online surveys for members of professional cardiology and cardiac surgery organisations. RESULTS: We screened 2,544 records, identified 322 eligible studies, and extracted data from 47. We identified 10 co-interventions and 70 potential confounders: review 31 (91%); interviews 19 (56%); surveys 31 (91%). 16/34 (47%) were identified by all three methods while, 3/34 (9%) were picked up by one method only. CONCLUSION: The review identified the majority of factors, but the interviews identified hard-to-measure factors such as perceived patient adherence and local prescribing culture. The methods could, in principle, be widely applied when designing or reviewing non-randomized studies of interventions (NRSI). |
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| ジャーナル名 | Journal of clinical epidemiology |
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| Pubmed追加日 | 2022/3/30 |
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| 投稿者 | Pufulete, Maria; Mahadevan, Kalaivani; Johnson, Thomas W; Pithara, Christalla; Redwood, Sabi; Benedetto, Umberto; Higgins, Julian P T; Reeves, Barnaby C |
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| 組織名 | Bristol Trials Centre (Clinical Trials and Evaluation Unit), Bristol Medical;School, University of Bristol, Bristol, UK; NIHR Biomedical Research Centre at;University Hospitals Bristol and Weston NHS Foundation Trust and the University;of Bristol, Bristol, UK. Electronic address: maria.pufulete@bristol.ac.uk.;Bristol Heart Institute, Bristol, UK.;The National Institute for Health Research Applied Research Collaboration West;(NIHR ARC West) at University Hospitals Bristol and Weston NHS Foundation Trust,;UK.;NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS;Foundation Trust and the University of Bristol, Bristol, UK; The National;Institute for Health Research Applied Research Collaboration West (NIHR ARC West);at University Hospitals Bristol and Weston NHS Foundation Trust, UK; Population;Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.;of Bristol, Bristol, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35346782/ |
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