| アブストラクト | Leukemia is one of the leading childhood malignancies, with acute lymphoblastic leukemia (ALL) being the most common type. Invasive fungal disease is a concerning problem also at pediatric hemato-oncology units. Available guidelines underline the need for antifungal prophylaxis and give recommendations for proper treatment in various clinical scenarios. Nonetheless, antifungal agents are often involved in drug-drug interaction (DDI) occurrence. The prediction of those interactions in the pediatric population is complicated because of the physiological differences in adults, and the lack of pharmacological data. In this review, we discuss the potential DDIs between antifungal agents and commonly used pharmaceutics in pediatric hemato-oncology settings, with special emphasis on the use of liposomal amphotericin B and ALL treatment. We obtained information from Micromedex((R)) and Drugs.com((R)) interaction checking databases and checked the EudraVigilance((R)) database to source the frequency of severe adverse drug reactions that resulted from antifungal drug interactions. Several major DDIs were identified, showing a favorable safety profile of echinocandins and liposomal amphotericin B. Interestingly, although there are numerous available drug interaction checking tools facilitating the identification of potential serious DDIs, it is important to use more than one tool, as the presented searching results may differ between particular checking programs. |
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| ジャーナル名 | Journal of clinical medicine |
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| 投稿日 | 2023/7/29 |
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| 投稿者 | Sienkiewicz-Oleszkiewicz, Beata; Salamonowicz-Bodzioch, Malgorzata; Slonka, Justyna; Kalwak, Krzysztof |
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| 組織名 | Department of Clinical Pharmacology, Faculty of Pharmacy, Wroclaw Medical;University, ul. Borowska 211a, 50-556 Wroclaw, Poland.;Department and Clinic of Pediatric Oncology, Hematology and Bone Marrow;Transplantation, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw,;Poland.;Gilead Sciences Poland Sp. z o.o., ul. Postepu 17A, 02-676 Warsaw, Poland. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37510753/ |
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