| アブストラクト | Eating disorders, characterized by abnormal eating, weight control behaviors or both include anorexia nervosa (AN) and bulimia nervosa (BN). We investigated their potential iatrogenic triggers, using real-world data from the WHO safety database (VigiBase(R)). VigiBase(R) was queried for all AN and BN reports. The reports were classified as ;pediatric' or ;adult' according to age. Disproportionality analyses relied on the Information Component (IC), in which a 95% confidence interval lower-end positivity was required to suspect a signal. Our queries yielded 309 AN and 499 BN reports. Isotretinoin was disproportionately reported in pediatric AN (IC 3.6; [2.6-4.3]), adult AN (IC 3.1; [1.7-4.0]), and pediatric BN (IC 3.9; [3.0-4.7]). Lamivudine (IC 4.2; [3.2-4.9]), nevirapine (IC 3.7; [2.6-4.6]), and zidovudine (IC 3.4; [2.0-4.3]) had the highest ICs in adult AN. AN was associated with isotretinoin, anticonvulsants in minors, and antiretroviral drugs in adults. In adults, BN was related to psychotropic and hormonally active drugs. Before treatment initiation, an anamnesis should seek out mental health conditions, allowing the identification of patients at risk of developing or relapsing into AN or BN. In addition to misuse, the hypothesis of iatrogenic triggers for AN and BN should also be considered. |
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| 投稿者 | Merino, Diane; Gerard, Alexandre Olivier; Destere, Alexandre; Askenazy, Florence; Dor, Emmanuelle; Benoit, Michel; Cherikh, Faredj; Drici, Milou-Daniel |
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| 組織名 | Department of Psychiatry, University Hospital of Nice, Nice, France; Department;of Pharmacology and Pharmacovigilance Center of Nice, University Hospital Center;of Nice, Nice, France.;Department of Pharmacology and Pharmacovigilance Center of Nice, University;Hospital Center of Nice, Nice, France; Universite Cote d'Azur Laboratory of;Molecular Physio Medicine (LP2M), UMR 7370, CNRS, Nice, France.;Hospital Center of Nice, Nice, France; Universite Cote d'Azur, Inria, CNRS,;Laboratoire J.A. Dieudonne, Maasai team, Nice, France.;Department of Child and Adolescent Psychiatry, Children's Hospitals of Nice,;CHU-Lenval Nice, France; CoBTek Laboratory, Universite Cote d'Azur, 06000 Nice,;France.;Department of Psychiatry, University Hospital of Nice, Nice, France.;Department of Addiction, University Hospital of Nice, Nice, France.;Hospital Center of Nice, Nice, France. Electronic address:;pharmacovigilance@chu-nice.fr. |
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