| アブストラクト | This retrospective cross-sectional study aims to investigate the prevalence and seriousness of drug-induced nephrotoxicity and to identify clinical predictors intensifying the seriousness of nephrotoxicity. Adverse drug events (ADEs) reported to the Korean Adverse Event Reporting System Database (KAERS DB) from January 2012 to December 2021 were investigated. The association between the seriousness and the etiologic drug was estimated in reporting odds ratio (ROR) based on disproportionality analysis. Logistic regression was utilized to recognize predictors associated with serious nephrotoxicity. The majority of ADEs were reported in ages 30 to 59, and immunosuppressants were the most etiologic medications. ADEs involving antibiotics, including vancomycin (ROR 0.268; 95% CI 0.129-0.557), were less likely to be serious. More than 93% of cyclosporine-related ADEs were serious nephrotoxicity, whereas tacrolimus was less likely to report serious nephrotoxicity (ROR 0.356; 95% CI 0.187-0.680). The risk of serious nephrotoxicity was decreased with aging (ROR 0.955; 95% CI 0.940-0.972) while increased in women (OR 2.700; 95% CI 1.450-5.008). Polypharmacy was associated with increased risk of interstitial nephritis (OR 1.019; 95% CI 1.001-1.038). However, further studies investigating the impact of clinical practice on ADE incidences as well as clinical prognosis related to nephrotoxicity are obligated. |
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| 投稿者 | Kim, Yujin; Choi, Chang-Young; Sunwoo, Yongjun; Go, Chaerin; Kim, Semi; Eom, Sae Hyun; Shin, Sooyoung; Choi, Yeo Jin |
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| 組織名 | Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul;02447, Republic of Korea.;Department of Internal Medicine, Ajou University Medical Center, Suwon 16499,;Republic of Korea.;Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447,;Department of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499,;Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou;University, Suwon 16499, Republic of Korea.;Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University,;Seoul 02447, Republic of Korea. |
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