| アブストラクト | PURPOSE: Sodium hypochlorite (NaOCl) is considered as the reference irrigation solution in endodontics. However, NaOCl-related accidents may occur, and non-dentist health professionals might under-recognize this rare adverse effect although it is potentially severe, with possible medical and aesthetic sequelae. We performed a literature review to provide to non-dentist healthcare professionals a large picture of symptoms, management and potential consequences of NaOCl accidents. METHODS: We queried PubMed and the French Pharmacovigilance database and retrieved 76 cases for analysis (70 from 57 published articles, and six from the database). RESULTS: The analysis showed that patients were mostly women (79%), aged around of 42 years, undergoing upper jawbone (74%) endodontic procedure. NaOCl concentration ranged from 1% to 10%, with 0.5 to 30 mL injected. Most cases (86%) corresponded to an accidental extrusion beyond the root apex to the periapical tissues, followed by tissular injection by error (8%) and extrusion into the maxillary sinus (3%). Local symptoms always occurred within 24 h, mostly pain (99%), edema (89%) and/or ecchymosis (61%). Complications were mainly neurological (29%), necrotic (22%) and cutaneous (9%). Most of patients (76%) fully recovered after medical management but 18 (24%) required surgical management. CONCLUSION: Any healthcare professional should be aware of the classical symptomatic triad of NaOCl accident with sudden pain, haemorrhage/ecchymosis and swelling, to start or recommend adequate management. Patients should be reassured, but a close follow-up is necessary to avoid delayed complication. |
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| ジャーナル名 | Fundamental & clinical pharmacology |
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| 投稿日 | 2024/1/25 |
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| 投稿者 | Kartit, Zahoua; Delacroix, Celine; Clement, Celine; Beurrier, Mathilde; Mouton-Faivre, Claudie; Petitpain, Nadine |
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| 組織名 | Centre Regional de Pharmacovigilance, CHRU Nancy-Brabois, Vandoeuvre-les-Nancy,;France.;Service de Dermatologie-allergologie, CHRU Nancy-Brabois, Vandoeuvre-les-Nancy,;Departement de Prevention-Epidemiologie-Economie de la Sante-Odontologie Legale,;CHRU Nancy, Faculte d'odontologie, Vandoeuvre-les-Nancy, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38268036/ |
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