| アブストラクト | OBJECTIVE: Several medications are associated with delirium; however, studies with adequate statistical power are limited, and it is difficult to determine the effects of the various concomitant medications used in clinical practice. Therefore, in this study, we aimed to comprehensively evaluate the safety signals of delirium-associated drugs using a spontaneous adverse event reporting system. METHOD: The JAPIC AERS (Food and Drug Administration Adverse Event Reporting System pre-processed by the Japan Pharmaceutical Information Center) was used for the analysis in this pharmacovigilance study. The reporting odds ratio (ROR) for delirium was adjusted for using multivariate logistic regression analysis with sex, age, indication, and melatonin receptor agonist use, and 22 drug categories were targeted as covariates. RESULTS: After excluding patients with missing information, 7,527,568 patients were included in the study. Delirium signals were detected even after adjusting for covariates in 17 drug categories, including benzodiazepines (adjusted ROR, 1.76; 95% confidence interval [CI], 1.64-1.89), opioids (adjusted ROR, 4.42; 95% CI, 4.21-4.64), and tricyclic antidepressants (adjusted ROR, 2.44; 95% CI, 2.20-2.71). CONCLUSIONS: These findings suggest that many drug classes, such as benzodiazepines, are independent risk factors for delirium and strengthen the evidence of an association between delirium and medications. |
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| ジャーナル名 | General hospital psychiatry |
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| 投稿日 | 2024/6/29 |
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| 投稿者 | Hatano, Masakazu; Sogawa, Rintaro; Shin, Kenji; Esumi, Satoru; Ishikawa, Akira; Mizumura, Ryosuke; Araki, Haruna; Yamada, Shigeki |
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| 組織名 | Department of Pharmacotherapeutics and Informatics, Fujita Health University;School of Medicine, Toyoake, Aichi, Japan. Electronic address:;hatanomasakazu@yahoo.co.jp.;Department of Pharmacy, Saga University Hospital, Nabeshima, Saga, Japan.;Electronic address: sogawari@cc.saga-u.ac.jp.;Department of Pharmacy, Iizuka Hospital, Fukuoka, Japan. Electronic address:;kshinh1@aih-net.com.;The Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan.;Electronic address: esumi-s@pharm.kobegakuin.ac.jp.;Department of Pharmacy, Saitama Medical University Hospital, Japan. Electronic;address: ishikawa.akira@1972.saitama-med.ac.jp.;address: mizumura.ryosuke@1972.saitama-med.ac.jp.;y0971102@gmail.com.;syamada@fujita-hu.ac.jp. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38941744/ |
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