| アブストラクト | Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a newly recognized syndrome mediated by anti-platelet factor 4 antibodies induced by Covid-19 adenovirus-vectored vaccines including ChAdOx1 nCoV-19 and Ad26.COV2.S. This study validated a proposed Brighton Collaboration case definition for VITT. A data collection form was developed and used to capture the variations in VITT criteria and assess their level of diagnostic certainty from adjudicated positive VITT case datasheets in Germany (n = 71), UK (n = 220), Australia (n = 203), and Taiwan (n = 56). We observed high prevalence of each component of the proposed VITT definition in positive cases (84%-100%), except for the occurrence of thrombosis or thromboembolism criterion in only 34% of VITT cases in Taiwan. The sensitivity of this proposed definition was 100% for Germany and UK, 92% for Australia, and 89% for Taiwan cases. These findings support the validity of this case definition for VITT. |
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| 投稿者 | Huang, Wan-Ting; Law, Barbara; Tran, Huyen; Schonborn, Linda; Huang, Wei-I; Buttery, Jim; Chen, Vivien Mun Yee; Greinacher, Andreas; Pavord, Sue |
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| 組織名 | Brighton Collaboration, Task Force for Global Health, Decatur, GA, USA; Global;Health Program, College of Public Health, National Taiwan University, Taipei,;Taiwan; National Taiwan University Children's Hospital, Taipei, Taiwan.;Electronic address: huangwt@ntu.edu.tw.;Brighton Collaboration, Task Force for Global Health, Decatur, GA, USA.;Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria,;Australia; The Alfred Hospital, Melbourne, Victoria, Australia.;University Medicine Greifswald, Institute for Transfusion Medicine, Greifswald,;Germany.;Taiwan Drug Relief Foundation, Taipei, Taiwan.;Department of Paediatrics, University of Melbourne and Epi-informatics, Murdoch;Childrens Research Institute, Melbourne, Victoria, Australia.;Department of Haematology, Concord Repatriation General Hospital and NSW Health;Pathology, Concord, NSW, Australia; ANZAC Research Institute, Concord, NSW,;Australia; Sydney Medical School, University of Sydney, Concord, NSW, Australia.;Oxford University Hospitals NHS Foundation Trust, Oxford, UK. |
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