| アブストラクト | BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are widely used in depression and other psychiatric disorders. Despite their efficacy, there is a growing concern about the risk of eye disorders. This study aims to explore the potential correlation between eye disorders and SSRIs utilizing real-world data. RESEARCH DESIGN AND METHODS: The data were extracted from the US FDA Adverse Event Reporting System database from 2004Q1 to 2023Q3. The analysis focused on the clinical characteristics, the ranking of adverse reactions, the time-to-onset, and the severity proportion of SSRI-related eye disorders. RESULTS: Our analysis revealed that SSRIs were significantly associated with eye disorders, with a higher risk of vision blurred with escitalopram, angle closure glaucoma with citalopram, and photopsia with paroxetine. The most common eye disorders were vision blurred, visual impairment, mydriasis, etc. Most of these adverse events occurred within the first 30 days of treatment. The reported incidence of severe eye disorders was 38.6% for SSRIs, with fluoxetine exhibiting the highest rate at 45.9%. CONCLUSION: Our study demonstrates a significant association between SSRIs and the risk of eye disorders. These findings provide crucial insights for clinicians when prescribing SSRIs and underscore the need to monitor eye health in patients receiving these medications. |
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| ジャーナル名 | Expert opinion on drug safety |
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| Pubmed追加日 | 2024/7/26 |
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| 投稿者 | Li, Jiahao; Zhong, Rujia; Guo, Yi; Zhang, Feng |
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| 組織名 | Department of General Practice and International Medicine, The Second Affiliated;Hospital of Zhejiang University School of Medicine, Hangzhou, China.;Department of Neurology, First Affiliated Hospital, Dalian Medical University,;Dalian, China.;Department of Neurology, The Second Affiliated Hospital of Zhejiang University;School of Medicine, Hangzhou, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39051730/ |
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