| アブストラクト | BACKGROUND: Electronic health records (EHRs) have the potential to be used to produce detailed disease burden estimates. In this study we created disease estimates using national EHR for three high burden conditions, compared estimates between linked and unlinked datasets and produced stratified estimates by age, sex, ethnicity, socio-economic deprivation and geographical region. METHODS: EHRs containing primary care (Clinical Practice Research Datalink), secondary care (Hospital Episode Statistics) and mortality records (Office for National Statistics) were used. We used existing disease phenotyping algorithms to identify cases of cancer (breast, lung, colorectal and prostate), type 1 and 2 diabetes, and lower back pain. We calculated age-standardised incidence of first cancer, point prevalence for diabetes, and primary care consultation prevalence for low back pain. RESULTS: 7.2 million people contributing 45.3 million person-years of active follow-up between 2000-2014 were included. CPRD-HES combined and CPRD-HES-ONS combined lung and bowel cancer incidence estimates by sex were similar to cancer registry estimates. Linked CPRD-HES estimates for combined Type 1 and Type 2 diabetes were consistently higher than those of CPRD alone, with the difference steadily increasing over time from 0.26% (2.99% for CPRD-HES vs. 2.73 for CPRD) in 2002 to 0.58% (6.17% vs. 5.59) in 2013. Low back pain prevalence was highest in the most deprived quintile and when compared to the least deprived quintile the difference in prevalence increased over time between 2000 and 2013, with the largest difference of 27% (558.70 per 10,000 people vs 438.20) in 2013. CONCLUSIONS: We use national EHRs to produce estimates of burden of disease to produce detailed estimates by deprivation, ethnicity and geographical region. National EHRs have the potential to improve disease burden estimates at a local and global level and may serve as more automated, timely and precise inputs for policy making and global burden of disease estimation. |
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| ジャーナル名 | Wellcome open research |
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| 投稿日 | 2024/8/2 |
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| 投稿者 | Aldridge, Robert W; Evans, Hannah E R; Yavlinsky, Alexei; Moayyeri, Alireza; Bhaskaran, Krishnan; Mathur, Rohini; Jordan, Kelvin P; Croft, Peter; Denaxas, Spiros; Shah, Anoop D; Blackburn, Ruth M; Moller, Henrik; Ng, Edmond S W; Hughes, Andrew; Fox, Sebastian; Flowers, Julian; Schmidt, Jurgen; Hayward, Andrew; Gilbert, Ruth; Smeeth, Liam; Hemingway, Harry |
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| 組織名 | Institute of Health Informatics, University College London, London, England, NW1;2DA, UK.;Faculty of Epidemiology & Population Health, London School of Hygiene and;Tropical Medicine, London, WC1E 7HT, UK.;Wolfson Institute of Population Health, Queen Mary University of London, London,;England, EC1M 6BQ, UK.;School of Medicine, Keele University, Staffordshire, England, ST5 5BG, UK.;Cancer Epidemiology & Population Health, King's College London, London, England,;WC2R 2LS, UK.;Department of Health and Social Care, Office for Health Improvement and;Disparities, London, SW1H 0EU, UK.;Institute of Epidemiology and Health Care, University College London, London,;England, WC1E 6BT, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39092423/ |
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