| アブストラクト | OBJECTIVE: To obtain updated estimates on the incidence and prevalence of systemic lupus erythematosus (SLE) in the UK, over the period 1990-2020, using the Clinical Practice Research Datalink (CPRD). METHODS: This was a retrospective cohort study using the CPRD covering the period 1990-2020. A case ascertainment algorithm was developed in line with best practice recommendations for observational research. Incidence was calculated per 100 000 person-years and point prevalence (at the mid-year point) calculated per 100 000. Results were stratified by sex. RESULTS: 9443 SLE cases were identified. 5278 incident cases were identified (4538 women, 740 men). The overall incidence rate was 5.47 (95% CI 5.33 to 5.62) cases per 100 000 person-years. Incidence rates decreased slightly across the study period, which was more pronounced for women than men. Point prevalence increased over time, from 21.4 (95% CI 17.68 to 25.67) per 100 000 in 1990 to 107.14 (95% CI 103.26 to 111.12) per 100 000 in 2020. CONCLUSIONS: The observed fivefold increase in prevalence of SLE over the last 30 years, in the context of a modest decline in incidence rate, may suggest improved outcomes in SLE and has important implications for healthcare service delivery and planning in the UK. |
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| ジャーナル名 | Lupus science & medicine |
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| 投稿日 | 2024/7/28 |
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| 投稿者 | Ellis, Jessica; McHugh, Neil; Pauling, John D; Bruce, Ian N; Charlton, Rachel; McGrogan, Anita; Skeoch, Sarah |
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| 組織名 | Department of Life Sciences, University of Bath, Bath, UK.;Rheumatology, Royal National Hospital for Rheumatic Diseases, Royal United;Hospitals Bath NHS Foundation Trust, Bath, UK.;Department of Rheumatology, North Bristol NHS Trust, Westbury on Trym, UK.;Centre for Musculoskeletal Research, The University of Manchester, Manchester,;UK.;Department of Life Sciences, University of Bath, Bath, UK sarah.skeoch1@nhs.net. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39067871/ |
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