| アブストラクト | BACKGROUND: To estimate the global trends and disease burden of Clostridioides difficile infection (CDI) and its correlation with worldwide antibiotic consumption. METHODS: Clostridioides difficile infection and antibiotic consumption data were retrieved from the Global Burden of Disease 2019, ResistanceMap-AntibiocUse, Food and Drug Administration (FDA) Adverse Event Reporting System, and Global Antimicrobial Resistance and Use Surveillance System. Jointpoint regression and age-period-cohort model were developed to show the global trends and burden of CDI. Correlation tests were calculated to explore the relationship between CDI and antibiotics. RESULTS: Globally, CDI is the most significant one with a high-rocketing burden increase rate among 13 pathogens causing diarrheal deaths and disability-adjusted life years (DALYs). The age-standardised death rate (ASDR) increased from 0.19 in 1990 to 0.43 in 2019, in which the elderly and females are at higher risk. A rapid increase in ASDR in high to middle sociodemographic index (SDI) regions such as North America (average annual percentage change (AAPC) = 7.71%), Andean (AAPC = 7.82%), and Southern Latin America (AAPC = 11.08%) was identified. Antibiotic consumption has a significant positive correlation with CDI with different risk stratifications. CONCLUSIONS: The global burden of CDI has continuously increased for the past 30 years, especially in high to middle-SDI regions. World antibiotic consumption showed a strong positive correlation with CDI with different risk stratification. More effective prevention and control measures should be implemented in these critical regions, with a specific emphasis on vulnerable populations, to mitigate the spread of epidemics. |
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| ジャーナル名 | Journal of global health |
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| 投稿日 | 2024/8/16 |
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| 投稿者 | Chen, Yonghao; Xie, Xiaoxi; Ge, Qintao; He, Xiaogang; Sun, Zhiyuan; Li, Yanni; Guo, Yaoyu; Geng, Chong; Li, Xiao; Wang, Chunhui |
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| 組織名 | Department of Gastroenterology and Hepatology, West China Hospital of Sichuan;University, Chengdu, Sichuan, PR China.;Department of Urology, The First Affiliated Hospital of Anhui Medical University,;Hefei, Anhui, PR China.;Translational Medical Research, Orthopaedics Department, Medical Faculty;Mannheim, Heidelberg University, Mannheim, Germany.;School of Computer Science and Technology, University of Science and Technology;of China, Hefei, Anhui, PR China.;Centre of Pancreatitis, West China Hospital of Sichuan University, Chengdu,;Sichuan, PR China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39148479/ |
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