| アブストラクト | Specific drugs are well known to have the capacity to induce Parkinson-like symptoms. Parkinson-like events are side effects that may persist for an extended period even after drug administration is discontinued. Although these events can be triggered by various drugs, the mechanisms underlying their diverse symptoms remain largely unclear. To investigate this, we used the Japanese Adverse Drug Event Reporting Database, which is maintained by the Pharmaceuticals and Medical Devices Agency, to analyze the risk factors associated with Parkinson-like events along with the associated drug trends and characteristics. Our findings indicate that similar to Parkinson's disease, age-related differences affect the onset of these reported events, with older individuals being more susceptible. Hierarchical clustering and principal component analysis revealed that the mechanisms triggering these Parkinson-like events are consistent across reports, suggesting a common underlying cause. However, even with a consistent mechanism, the side effects can vary depending on the site of action. These insights underline the importance of the swift identification of the drugs suspected of causing these events and the implementation of measures to reduce their side effects. |
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| ジャーナル名 | Pharmaceuticals (Basel, Switzerland) |
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| 投稿日 | 2024/8/31 |
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| 投稿者 | Kikegawa, Mami; Sone, Hideko; Uesawa, Yoshihiro |
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| 組織名 | Department of Medical Molecular Informatics, Meiji Pharmaceutical University,;2-522-1 Noshio, Kiyose 204-8588, Japan.;Department of Kampo Medicine, Yokohama University of Pharmacy, Yokohama 245-0066,;Japan.;Environmental Health and Prevention Research Unit, Department of Health Science,;Graduate School of Pharmaceutical Sciences, Yokohama University of Pharmacy,;Yokohama 245-0066, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39204204/ |
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