| アブストラクト | The role of real-world data, collected from clinical practice rather than clinical trials, has become increasingly important for investigating real-life situations, such as treatment effects. In Japan, evidence on hypertension, cardiovascular diseases, and kidney diseases using real-world data is increasing. These studies are mainly based on "the insurer-based real-world data" collected as electronic records, including data from health check-ups and medical claims such as JMDC database, DeSC database, the Japan Health Insurance Association (JHIA) database, or National Databases of Health Insurance Claims and Specific Health Checkups (NDB). Based on the insurer-based real-world data, traditional but finely stratified associations between hypertension and cardiovascular or kidney diseases can be explored. The insurer-based real-world data are also useful for pharmacoepidemiological studies that capture the distribution and trends of drug prescriptions; combined with annual health check-up data, the effectiveness of drugs can also be examined. Despite the usefulness of insurer-based real-world data collected as electronic records from a wide range of populations, we must be cautious about several points, including issues regarding population uncertainty, the validity of cardiovascular outcomes, the accuracy of blood pressure, traceability, and biases, such as indication and immortal biases. While a large sample size is considered a strength of real-world data, we must keep in mind that it does not overcome the problem of systematic error. This review discusses the usefulness and pitfalls of insurer-based real-world data in Japan through recent examples of Japanese research on hypertension and its association with cardiovascular or kidney disease. |
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| ジャーナル名 | Hypertension research : official journal of the Japanese Society of Hypertension |
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| 投稿日 | 2024/9/12 |
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| 投稿者 | Satoh, Michihiro; Nakayama, Shingo; Toyama, Maya; Hashimoto, Hideaki; Murakami, Takahisa; Metoki, Hirohito |
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| 組織名 | Division of Public Health, Hygiene and Epidemiology, Tohoku Medical and;Pharmaceutical University, Sendai, Japan. satoh.mchr@tohoku-mpu.ac.jp.;Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank;Organization, Tohoku University, Sendai, Japan. satoh.mchr@tohoku-mpu.ac.jp.;Department of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital,;Sendai, Japan. satoh.mchr@tohoku-mpu.ac.jp.;Pharmaceutical University, Sendai, Japan.;Division of Nephrology and Endocrinology, Faculty of Medicine, Tohoku Medical and;Organization, Tohoku University, Sendai, Japan.;Department of Nephrology, Self-Defense Forces Sendai Hospital, Sendai, Japan.;Division of Aging and Geriatric Dentistry, Department of Rehabilitation;Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.;Tohoku Institute for Management of Blood Pressure, Sendai, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39261703/ |
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