| アブストラクト | BACKGROUND: Prostate cancer is one of the most common malignancies in men worldwide, and prostate-specific antigen (PSA) screening is widely used for its early detection. Drug use may affect PSA levels, but the effect for most drugs is currently unknown. METHODS: This study first investigated drugs related to PSA changes through the Food and Drug Administration Adverse Event Reporting System (FAERs) database, and then used a Mendelian randomization (MR) method to explore the causal relationship between specific drugs and PSA changes using a genome-wide association study (GWAS) data. The statistical analysis software SAS and R were used in the study. RESULTS: Through analysis of the FAERs database, 22 drugs were found to be associated with an increase in PSA, and 14 drugs were associated with a decrease in PSA. MR analysis showed that the use of tamsulosin may lead to an increase in PSA. Heterogeneity test, horizontal pleiotropy test and leave-one-out Analysis verified the stability of the results. MR analyses for other drugs did not show statistical significance. CONCLUSION: This study provided a basis for better understanding the impact of medications on prostate health, helping to avoid overdiagnosis or underdiagnosis of high-risk patients. However, research still requires larger-scale validation and in-depth exploration. |
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| ジャーナル名 | Expert opinion on drug safety |
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| 投稿日 | 2024/9/14 |
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| 投稿者 | Zhang, Wei; Jiang, Xin; Jia, Zhisheng; Tian, Hua; Wang, Renjie; Ma, Yuepeng; Ma, Zhifang; Wang, Xin; Hu, Caoyang |
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| 組織名 | Department of Urology, First Hospital of Shanxi Medical University, Taiyuan,;Shanxi, China.;Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan,;Department of Operating Room, First Hospital of Shanxi Medical University,;Taiyuan, Shanxi, China.;Department of Urology, Sixth Hospital of Shanxi Medical University, Taiyuan,;Department of High School, Jinzhong Boya Peiwen Experimental School, Taiyuan, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39276000/ |
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