| アブストラクト | BACKGROUND: Anti-herpesvirus drug safety profiles have not been systematically compared. Understanding variations in adverse events (AEs) could provide reference for rational clinical use. METHODS: We collected data on acyclovir, ganciclovir, valaciclovir, and foscarnet from the FDA Adverse Event Reporting System (FAERS) database from Q1 2004 to Q3 2023. Disproportionality analyses were conducted to evaluate the risk of AEs. RESULTS: All drugs exhibited significant associations with hematotoxicity, with ganciclovir and foscarnet being more myelosuppressive. The correlation with renal impairment ranked as follows: foscarnet, ganciclovir, valaciclovir, and acyclovir (ROR = 16.72, 7.06, 3.51, and 2.02, respectively). Regarding hepatotoxicity, ganciclovir was associated with acute-on-chronic liver failure (ROR = 52.83), and foscarnet was associated with fulminant hepatitis (ROR = 49.91). In the nervous system, acyclovir showed the highest intensity of neurotoxicity (ROR = 14.95). Valaciclovir ranked first in toxic encephalopathy (ROR = 64.70). Foscarnet showed the highest intensity of status epilepticus (ROR = 6.45). Besides, acyclovir showed the strongest association with severe cutaneous adverse reactions (SCARs). CONCLUSIONS: Our study revealed differences in safety profiles of four anti-herpesvirus medications. Ganciclovir exhibited the highest risk of hematotoxicity but appeared relatively safe in seizures and SCARs. Foscarnet was more likely to induce nephrotoxicity, seizures, and electrolyte imbalances than others. Acyclovir and valaciclovir were strongly associated with plasmacytosis, neurotoxicity, and SCARs. |
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| ジャーナル名 | Expert opinion on drug safety |
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| 投稿日 | 2024/10/8 |
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| 投稿者 | He, Dan; Kong, Dexuan; Zeng, Yanbin; Han, Meifen; Zhang, Shunguo; Li, Zhiling |
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| 組織名 | Department of Pharmacy, Shanghai Children's Medical Center, Shanghai Jiao Tong;University School of Medicine, Shanghai, China.;Department of Pharmacy, Shengli Oilfield Central Hospital, Dongying, Shandong,;China.;Department of Pharmacy, Women and Children's Hospital, School of Medicine, Xiamen;University, Xiamen, Fujian, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39377277/ |
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