| アブストラクト | BACKGROUND: Population-based incidence data on young-adult-onset type 1 diabetes and type 2 diabetes are limited. We aimed to examine secular trends in the incidence of diagnosed type 1 diabetes and type 2 diabetes with an age of onset between 15 and 39 years. METHODS: In this multicountry aggregate data analysis, we assembled eight administrative datasets from high-income jurisdictions and countries (Australia, Denmark, Finland, Hungary, Japan, Scotland, South Korea, and Spain [Catalonia]) that had appropriate data available from an international diabetes consortium (GLOBODIAB) describing incidence by diabetes type among people aged 15-39 years from 2000 to 2020. We modelled type 1 diabetes and type 2 diabetes incidence rates using Poisson regression including age and calendar time by sex. FINDINGS: During the years 2000-20, there were 349 591 incident diabetes (both types) cases from 346 million person-years of follow-up among people aged 15-39 years. Over time, there was no statistically significant change in the incidence of type 1 diabetes in Hungary and Japan. The incidence of type 1 diabetes significantly increased in Australia, Denmark, Finland, Scotland, South Korea, and Spain, with annual changes ranging from 0.5% to 6.0%. The incidence of type 2 diabetes significantly increased in four of eight jurisdictions (Denmark, Finland, Japan, and South Korea), with annual increases from 2.0% to 8.5%. The magnitude of increase in incidence of type 2 diabetes was greater in Asian than non-Asian jurisdictions. There was no statistically significant change in type 2 diabetes incidence in Australia and Hungary. The incidence of type 2 diabetes significantly decreased in Scotland and Spain, with annual changes of -0.7% and -1.5%, respectively. INTERPRETATION: There is variability in the trajectory of the incidence of young-adult-onset type 2 diabetes among high-income countries or jurisdictions, with a greater evidence of increase in Asian than non-Asian countries. Evolving trends in the incidence of type 1 and type 2 diabetes in young adults call for the ongoing surveillance of diabetes incidence and a greater research focus on this population. FUNDING: US Centers for Disease Control and Prevention, Diabetes Australia Research Programme, and Victoria State Government Operational Infrastructure Support Programme. |
|---|
| 投稿者 | Magliano, Dianna J; Chen, Lei; Morton, Jedidiah I; Salim, Agus; Carstensen, Bendix; Gregg, Edward W; Pavkov, Meda E; Arffman, Martti; Colhoun, Helen M; Ha, Kyoung Hwa; Imamura, Tomoaki; Jermendy, Gyorgy; Kim, Dae Jung; Kiss, Zoltan; Mauricio, Didac; McGurnaghan, Stuart J; Nishioka, Yuichi; Wild, Sarah H; Winell, Klas; Shaw, Jonathan E |
|---|
| 組織名 | Department of Diabetes and Population Health, Baker Heart and Diabetes Institute,;Melbourne, VIC, Australia; School of Public Health and Preventive Medicine,;Monash University, Melbourne, VIC, Australia. Electronic address:;dianna.magliano@baker.edu.au.;Melbourne, VIC, Australia.;Melbourne, VIC, Australia; Centre for Medicine Use and Safety, Monash University,;Melbourne, VIC, Australia; Melbourne School of Population and Global Health, The;University of Melbourne, Melbourne, VIC, Australia; School of Mathematics and;Statistics, The University of Melbourne, Melbourne, VIC, Australia.;Clinical Epidemiology, Steno Diabetes Centre Copenhagen, Herlev, Denmark.;School of Population Health, Royal College of Surgeons in Ireland, University of;Medicine and Health Sciences, Dublin, Ireland; Department of Epidemiology and;Biostatistics, School of Public Health, Imperial College London, London, UK.;Division of Diabetes Translation, Centers for Diseases Control and Prevention,;Atlanta, GA, USA.;Department of Public Health and Welfare, Finnish Institute for Health and;Welfare, Helsinki, Finland.;Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.;Department of Endocrinology and Metabolism, Ajou University School of Medicine,;Suwon, South Korea.;Department of Public Health, Health Management and Policy, Nara Medical;University, Nara, Japan.;3rd Medical Department, Bajcsy-Zsilinszky Hospital, Budapest, Hungary.;2nd Department of Medicine and Nephrological Center, Medical Faculty, University;of Pecs, Pecs, Hungary.;CIBER of Diabetes and Associated Metabolic Diseases, Instituto de Salud Carlos;III, Barcelona, Spain; Institut Catala de la Salut, Unitat de Suport a la Recerca;Barcelona Ciutat, Institut Universitari d'Investigacio en Atencio Primaria Jordi;Gol, Barcelona, Spain; Department of Endocrinology, Hospital de la Santa Creu i;Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.;Usher Institute, University of Edinburgh, Edinburgh, UK.;Welfare, Helsinki, Finland; Unit of Public Health, University of Turku, 20014;University of Turku, Finland.;Monash University, Melbourne, VIC, Australia; School of Life Sciences, La Trobe;University, Melbourne, VIC, Australia. |
|---|
