| アブストラクト | BACKGROUND: Drug-induced cystitis (DIC) significantly impacts patient quality of life and treatment outcomes. This study investigates the incidence and characteristics of DIC using data from the FDA Adverse Event Reporting System (FAERS). METHODS: We reviewed FAERS reports related to cystitis from Q1 2004 to Q1 2024, compiling a list of potential causative drugs. The top 50 drugs with the highest number of cystitis reports were ranked. Statistical disproportionality analyses, including Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR), were used to detect unusually high reporting frequencies of cystitis associated with specific drugs. RESULTS: From 17,703,515 FAERS reports spanning 2004-2024, 36399 involved cystitis. The majority of implicated drugs were antineoplastics. Busulfan, BCG, and mitomycin had the highest ROR and PRR values. Additionally, drugs such as defibrotide sodium, milrinone, and dyazide, which do not have cystitis listed on their labels, were identified, highlighting the need for increased clinical vigilance and awareness. CONCLUSION: The findings underscore the importance of ongoing pharmacovigilance in identifying and characterizing DIC. Further clinical studies are warranted to validate these associations and to develop strategies for mitigating the risk of DIC, thereby improving patient safety and treatment outcomes. |
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| ジャーナル名 | Expert opinion on drug safety |
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| Pubmed追加日 | 2024/11/16 |
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| 投稿者 | Zheng, Fuchun; Yang, Xin; Li, Sheng; Yuan, Yuyang; Wang, Zhipeng; Xiong, Situ; Fu, Bin; Liu, Wei; Lu, Qi |
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| 組織名 | Department of Urology, The First Affiliated Hospital, Jiangxi Medical College,;Nanchang University, Nanchang, China.;Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China.;Department of Nephrology, The First Affiliated Hospital, Jiangxi Medical College,;Department of Emergency Surgery, The First Affiliated Hospital, Jiangxi Medical;College, Nanchang University, Nanchang, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39549041/ |
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