| アブストラクト | Nephrotoxic adverse events (AEs) have been observed in patients with breast cancer receiving cyclin-dependent kinase (CDK) 4/6 inhibitors. This study aimed to evaluate the risk of nephrotoxicity associated with these inhibitors through a meta-analysis of 17 randomized controlled trials involving 19,638 patients. The results indicate a significant increase in all-grade nephrotoxic AEs, including elevated blood creatinine levels, acute kidney injury, and renal impairment (RR = 3.12, 95% CI [2.11, 4.63]). The incidence of grade 3 or higher nephrotoxicity was also more prevalent among treated patients (RR = 3.12, 95% CI [1.74, 5.58]). Subgroup analyses revealed varying risks among 4 different CDK 4/6 inhibitors. Furthermore, analysis of FDA Adverse Event Reporting System data corroborated these findings, emphasizing the occurrence of nephrotoxicity in real-world settings. Clinicians should remain vigilant in monitoring renal function indicators when prescribing CDK4/6 inhibitors. |
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| ジャーナル名 | iScience |
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| Pubmed追加日 | 2024/12/6 |
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| 投稿者 | Cui, Jiayong; Sun, Jinquan; Zhou, Xueying; Li, Yi; Zhao, Jiuda; Shen, Guoshuang |
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| 組織名 | Breast Disease Diagnosis and Treatment Center, Affiliated Hospital of Qinghai;University, Xining, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39640578/ |
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