Sex differences among sleep disordered breathing, obesity, and metabolic comorbidities; the Nagahama study.

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Sex differences among sleep disordered breathing, obesity, and metabolic comorbidities; the Nagahama study.

Sex differences among sleep disordered breathing, obesity, and metabolic comorbidities; the Nagahama study.

アブストラクト	BACKGROUND: Although sex differences in the prevalence of sleep disordered breathing (SDB) is recognized, whether a sex difference exists among obese individuals with SDB with or without comorbidities has not been well investigated. This study aimed to explore the relationships of sex differences among SDB, obesity, and metabolic comorbidities. METHODS: This study evaluated 7713 community participants with nocturnal oximetry >/=2 nights. SDB was assessed by the 3% oxygen desaturation index corrected for sleep duration obtained by wrist actigraphy (Acti-ODI3%), and moderate-to-severe SDB was defined as Acti-ODI3% levels >/=15/h. Obesity was defined as body mass index >/=25 kg/m(2). RESULTS: The prevalence of moderate-to-severe SDB was 21.6%/0% among those with obesity/without obesity in women under 40 years old. The adjusted odds ratios for moderate-to-severe SDB in those with both diabetes/metabolic syndrome and obesity compared to others were 86.4 (95%CI 24.2-308.8)/40.4 (95%CI 15.0-108.8) in pre-menopausal women. The association among SDB, obesity, and metabolic comorbidities showed significant interactions between pre-menopausal women and men or post-menopausal women. CONCLUSIONS: Sex differences exist among the prevalence of SDB and the relationships among SDB, obesity, and metabolic comorbidities. Especially, pre-menopausal women are more vulnerable to the consequences of obesity. SDB prevalence may be impacted by the coexistence of obesity and diabetes or metabolic syndrome in pre-menopausal women.
ジャーナル名	Respiratory investigation
Pubmed追加日	2024/12/5
投稿者	Matsumoto, Takeshi; Murase, Kimihiko; Tabara, Yasuharu; Minami, Takuma; Kanai, Osamu; Sunadome, Hironobu; Takahashi, Naomi; Hamada, Satoshi; Tanizawa, Kiminobu; Wakamura, Tomoko; Komenami, Naoko; Setoh, Kazuya; Kawaguchi, Takahisa; Morita, Satoshi; Takahashi, Yoshimitsu; Nakayama, Takeo; Sato, Susumu; Hirai, Toyohiro; Matsuda, Fumihiko; Chin, Kazuo
組織名	Department of Respiratory Medicine, Kyoto University Graduate School of Medicine,;54 kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507, Japan; Department of;Respiratory Medicine, Saiseikai-Noe Hospital, 1-3-25 Furuichi, Jyoto-ku, Osaka,;536-0001, Japan.;Department of Respiratory Care and Sleep Control Medicine, Kyoto University;Graduate School of Medicine, 54 kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507,;Japan.;Center for Genomic Medicine, Kyoto University Graduate School of Medicine, 53;kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507, Japan; Graduate School of;Public Health, Shizuoka Graduate University of Public Health, 4-27-2 Kita Ando,;Aoi-ku, Shizuoka, 420-0881, Japan.;Department of Primary Care and Emergency Medicine, Kyoto University Graduate;School of Medicine, 54 kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507, Japan.;54 kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507, Japan.;Department of Advanced Medicine for Respiratory Failure, Kyoto University;Nursing Science, Human Health Sciences, Kyoto University Graduate School of;Medicine, 53 kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507, Japan.;Department of Food and Nutrition, Kyoto Women's University, 35 Kitahiyoshi-cho,;Imakumano, Higashiyama-ku, Kyoto, 605-8501, Japan.;kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507, Japan.;Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate;Department of Health Informatics, School of Public Health, Kyoto University;Graduate School of Medicine, 53 kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507,;kawahara-cho, shogoin, sakyo-ku, Kyoto, 606-8507, Japan; Department of Sleep;Medicine and Respiratory Care, Division of Sleep Medicine, Nihon University of;Medicine, 30-1 Ohyaguchi kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan.;Electronic address: chin.kazuo@nihon-u.ac.jp.
Pubmed リンク	https://www.ncbi.nlm.nih.gov/pubmed/39632326/