| アブストラクト | BACKGROUND: Behcet's disease (BD) is an autoinflammatory disease that can affect multiple organs, including the gastrointestinal tract. Conventional management comprises anti-inflammatory drugs such as glucocorticoids (GCs) and/or immunomodulators that alleviate symptoms. The introduction of biological agents that target tumor necrosis factor alpha (TNF-alpha) has improved disease management. The goal of this work was to analyze the current prevalence and incidence of total BD and gastrointestinal Behcet's disease (GIBD) in Japan, and examine treatment trends, especially regarding the use of TNF-alpha inhibitors (TNFalphai). METHODS: We performed a retrospective descriptive observational study in which BD and GIBD demographic trends, medical treatment patterns, and reported adverse events (AEs) were assessed among patients with data recorded between 2017 and 2021 in the Japan Medical Data Center Claims Database (now JMDC Inc.). RESULTS: Prevalence of BD and GIBD in Japan during the observation period increased at an annual rate of + 3% and + 4%, respectively, while incidence decreased by - 5% and - 2%, with a more prominent decline in confirmed GIBD cases (- 15%). Although GCs were the most common initial treatment administered, use of TNFalphai for BD and GIBD management increased by + 5.6% and + 8.1%, respectively. Severe AEs (mainly pneumonia and GI-associated AEs) were reported in 40% of patients receiving TNFalphai; however, a high retention rate (of up to 80%) was observed 3 years after treatment initiation. CONCLUSION: The use of TNFalphai for GIBD treatment has increased in Japan in recent years. Additional research is necessary to further evaluate TNFalphai effectiveness in GIBD and other BD subtypes. |
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| ジャーナル名 | Journal of gastroenterology |
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| Pubmed追加日 | 2024/12/7 |
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| 投稿者 | Hisamatsu, Tadakazu; Naganuma, Makoto; Pinton, Philippe; Takeno, Mitsuhiro |
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| 組織名 | Department of Gastroenterology and Hepatology, Kyorin University School of;Medicine, Tokyo, Japan.;Division of Gastroenterology and Hepatology, Third Department of Internal;Medicine, Kansai Medical University, Hirakata, Osaka, Japan.;Clinical and Translational Sciences, Ferring Pharmaceuticals, 2770, Kastrup,;Denmark.;Department of Allergy and Rheumatology, Nippon Medical School Musashi Kosugi;Hospital, Kawasaki, Kanagawa, Japan. m-takeno@nms.ac.jp. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39643815/ |
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