| アブストラクト | Data addressing safety concerns related to potential drug interactions between cannabis-derived products and pharmaceutical medications in the pediatric population are lacking. In this study, we retrieved case reports through a published literature search using PubMed and spontaneous reporting data using the Food and Drug Administration's Adverse Event Reporting System (FAERS) to identify potential cannabis- and cannabinoid-drug interactions in individuals younger than 18 years old. To evaluate the published case reports, we used the Drug Interaction Probability Scale (DIPS), a 10-item questionnaire designed to discern the causal relationship between a potential drug interaction and adverse drug reactions (ADRs). FAERS reports were deduplicated and analyzed to gather information regarding patient demographics, associated drugs, nature of the ADRs, outcomes, professions of the reporters, and reporting timelines. Seven published case reports and 9142 FAERS ADRs reports were included in the final analysis. Based on the findings, caution is warranted when cannabis or cannabinoids are used in combination with prescribed medications, including methadone, everolimus, fluoxetine, and paroxetine. Cannabinoids may inhibit drug-metabolizing enzymes, including several cytochrome P450s, leading to increased drug exposure and potentially, an increased risk for ADRs. |
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| ジャーナル名 | Pharmacology research & perspectives |
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| Pubmed追加日 | 2024/12/25 |
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| 投稿者 | Chapin, Maryann R; Kane-Gill, Sandra L; Li, Xiaotong; Abanyie, Kojo; Taneja, Sanya B; Egbert, Susan; Paine, Mary F; Boyce, Richard D |
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| 組織名 | School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.;Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh,;Pennsylvania, USA.;Intelligent Systems Program, University of Pittsburgh, Pittsburgh, Pennsylvania,;USA.;Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada.;Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical;Sciences, Washington State University, Spokane, WA, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39719830/ |
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