| アブストラクト | BACKGROUND: Constipation commonly coexists with heart failure (HF) and can increase blood pressure because of straining during defecation and accompanying mental stress. Daikenchuto, a Japanese herbal medicine to ameliorate gastrointestinal motility, may be effective as a complement to laxatives in improving outcomes in patients with HF and constipation. METHODS AND RESULTS: We used the Diagnosis Procedure Combination database to identify patients aged >/=65 years who were admitted for HF, had constipation, and were discharged alive between April 2016 and March 2022. We divided the 115,544 eligible patients into 2 groups according to the prescription of Daikenchuto in addition to laxatives at discharge and compared the incidence of 1-year HF readmission using 1 : 4 propensity score matching. Daikenchuto was prescribed at discharge in 3,315 (2.9%) patients. In the unmatched cohort, patients treated with Daikenchuto were more often male and had a higher prevalence of malignancy than those treated without Daikenchuto. In the 1 : 4 propensity score-matched cohort (3,311 and 13,243 patients with and without Daikenchuto, respectively), no significant difference was noted in 1-year HF readmission between the groups (22.2% vs. 21.9%; hazard ratio=1.02, 95% confidence interval=0.94-1.11). This result was consistent across clinically relevant subgroups except for renal disease. CONCLUSIONS: Complementary use of Daikenchuto in combination with laxatives was not associated with a lower incidence of HF readmission in patients with HF and constipation. |
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| ジャーナル名 | Circulation reports |
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| Pubmed追加日 | 2025/2/11 |
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| 投稿者 | Isogai, Toshiaki; Morita, Kojiro; Okada, Akira; Michihata, Nobuaki; Matsui, Hiroki; Miyawaki, Atsushi; Yasunaga, Hideo |
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| 組織名 | Department of Cardiology, Tokyo Metropolitan Tama Medical Center Tokyo Japan.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo Tokyo Japan.;Department of Nursing Administration and Advanced Clinical Nursing, Division of;Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo;Tokyo Japan.;Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate;School of Medicine, The University of Tokyo Tokyo Japan.;Cancer Prevention Center, Chiba Cancer Center Research Institute Chiba Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo Tokyo Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39931709/ |
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