| アブストラクト | BACKGROUND: Edaravone is a novel free radical scavenger utilized to treat amyotrophic lateral sclerosis (ALS). However, long-term safety data remain limited. RESEARCH DESIGN AND METHODS: Adverse event reports related to edaravone from the second quarter of 2017 to the second quarter of 2024 were extracted from the US Food and Drug Administration (FDA) Adverse Event Reporting System database (FAERS). Disproportionality analysis was conducted utilizing the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS) algorithms. RESULTS: A total of 3,149 adverse event reports related to edaravone were analyzed. The most common adverse reactions included systemic disorders and administration site reactions, nervous system disorders, respiratory system disorders, and surgical and medical procedures. New adverse reaction signals included disseminated intravascular coagulation, gastric fistula, sputum retention, excessive salivation, fractures, elevated cystatin C. The median onset time for adverse events was 43 days (interquartile range: 7-173 days). CONCLUSION: This study confirmed previously reported adverse events and identified several new ones associated with edaravone. These findings provide valuable insights for optimizing ALS patient management and highlight the need for further research into the mechanisms of these adverse reactions. |
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| ジャーナル名 | Expert opinion on drug safety |
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| Pubmed追加日 | 2025/2/21 |
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| 投稿者 | Peng, Tao; Hu, Nan; Huang, Lan; Kang, Yalong; Yan, Yongmei; Zhang, Hui; Wan, Dongping; Jin, Xiaxia; Yang, Yifan |
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| 組織名 | First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang,;Shaanxi, China.;Department of Encephalopathy, Affiliated Hospital of Shaanxi University of;Chinese Medicine, Xianyang, Shaanxi, China.;Orthopaedics of Extremities, The First Affiliated Hospital of Guangxi University;of Chinese Medicine, Nanning, Guangxi, China.;Mational Resource Center for Chinese Materia Medica, China Academy of Chinese;Medical Sciences, Beijing, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39982214/ |
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