| アブストラクト | Hematologic malignancies are a global public health concern, with high mortality rates in patients requiring critical care. The role of chemotherapy during intensive care unit (ICU) admission in this context remains unclear. This study aimed to analyze trends in survival rates based on chemotherapy timing and examine patient characteristics, ICU treatments, and clinical outcomes in each group. Using the Japanese Diagnosis Procedure Combination inpatient database, data from 21,837 patients aged >/= 18 years who were hospitalized for hematologic malignancies and admitted to ICUs between April 1, 2012, and March 31, 2022, were analyzed. Patients were categorized based on chemotherapy timing as follows: no chemotherapy (NC), chemotherapy before ICU admission (CB), chemotherapy during ICU admission (CD), and chemotherapy after ICU discharge (CA). Mortality trends were assessed, with in-hospital mortality as the primary outcome variable. The CB group had the highest mortality rate, which decreased over time (61.2% in 2012 to 46.2% in 2021). The CD group had stable mortality rates (24.2% in 2012 and 22.6% in 2021), with a notable proportion of patients (55.4%) discharged home. These findings highlight the need for further investigation into the factors influencing ICU outcomes in patients receiving chemotherapy. |
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| ジャーナル名 | Scientific reports |
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| Pubmed追加日 | 2025/5/15 |
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| 投稿者 | Iwasaki, Yudai; Tarasawa, Kunio; Kamio, Tadashi; Kaiho, Yu; Ikumi, Saori; Yabuki, Shizuha; Fushimi, Kiyohide; Fujimori, Kenji; Yamauchi, Masanori |
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| 組織名 | Department of Anesthesiology and Perioperative Medicine, Tohoku University;Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575,;Japan. yudai.i0213@gmail.com.;Department of Emergency Medicine and Critical Care Medicine, Tochigi Prefectural;Emergency and Critical Care Centre, Imperial Foundation Saiseikai Utsunomiya;Hospital, Utsunomiya, Japan. yudai.i0213@gmail.com.;Department of Health Administration and Policy, Tohoku University Graduate School;of Medicine, Sendai, Japan.;Department of Anesthesiology and Critical Care Medicine, Jichi Medical University;Saitama Medical Center, Saitama, Japan.;Japan.;AI Lab, Tohoku University Hospital, Sendai, Japan.;Department of Health Policy and Informatics, Graduate School of Medical and;Dental Sciences, Institute of Science Tokyo, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40369060/ |
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