| アブストラクト | INTRODUCTION: We aimed to examine a cohort of people with diabetes to prospectively determine the association between diabetes therapy-related quality of life (DTR-QOL) and the subsequent risk of all-cause mortality. METHODS: Longitudinal data of 3795 individuals with diabetes were obtained from a single-center diabetes registry from 2011. To assess the association between DTR-QOL at baseline and the subsequent risk of all-cause mortality, a Cox proportional hazards model was used with adjustment for baseline potential confounders (age, sex, duration of diabetes, body mass index [BMI], glycated hemoglobin [HbA1c] level, urinary albumin/creatinine ratio, history of diabetic retinopathy, symptomatic diabetic neuropathy, medical history, type of diabetes, and diabetes prescriptions). RESULTS: We observed 425 deaths during a median follow-up of 8.7 years. The median (interquartile range) age and HbA1c level were 66 (60-74) years and 6.9% (6.7-8.1%), respectively. The DTR-QOL was significantly associated with younger age, female sex, higher BMI, higher HbA1c level, higher proportion of symptomatic diabetic neuropathy, higher proportion of diabetic retinopathy, and higher proportion of insulin use. In total, 425 deaths occurred during the study period. Compared with the third tertile group of DTR-QOL scores, the hazard ratios (HRs) were consistently 1.38 times higher in the first tertile group. Lower scores on "burden on social activities and daily activities" domain were associated with a higher HR, while lower scores on the other domains ("anxiety and dissatisfaction with therapy," "hypoglycemia," and "satisfaction with therapy") were not. CONCLUSION: A lower QOL related to diabetes therapy in people with diabetes was found to be associated with an increased risk of future mortality. Graphical Abstract available for this article. |
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| ジャーナル名 | Diabetes therapy : research, treatment and education of diabetes and related disorders |
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| Pubmed追加日 | 2025/6/10 |
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| 投稿者 | Nishioka, Yuichi; Hayashino, Yasuaki; Kurosawa, Kentaro; Takano, Kiyoko; Matsunaga, Satoshi; Okamura, Shintaro; Tsujii, Satoru; Ishii, Hitoshi |
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| 組織名 | Department of Public Health, Health Management and Policy, Nara Medical;University, 840, Shijo-cho, Kashihara, Nara, Nara, 634-8521, Japan.;y_n@naramed-u.ac.jp.;Department of Endocrinology, Tenri Hospital, Tenri, Nara, Japan.;Department of Doctor-Patient Relationships, Nara Medical University, Nara, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40493295/ |
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