| アブストラクト | OBJECTIVE: To determine factors associated with recurrent attacks of acute wheeze in preschool children. DESIGN: Retrospective cohort study. SETTING: English primary electronic health data from the Clinical Practice Research Datalink linked with hospital data from Hospital Episode Statistics. PARTICIPANTS: 42 820 children aged 5 years or under with at least one acute wheeze presentation between 1 January 2013 and 31 December 2014. EXPOSURES: Demographic and clinical variables including age, sex, ethnicity, deprivation quintile, clinical comorbidities and previous asthma medication prescriptions and acute attacks were included in multivariable analyses. MAIN OUTCOME MEASURES: Further healthcare presentation with an acute wheeze/asthma attack within 12 months. RESULTS: Almost 40% (16 962/42 820) of children had a further attack within 12 months. The strongest predictors were hospitalisation with the index episode (RR 1.42; 95% CI 1.39 to 1.45) and an attack in the previous year (1.27; 1.22 to 1.32). Male sex (RR 1.06; 95% CI 1.03 to 1.08), South Asian ethnicity (1.08; 1.04 to 1.12), atopy (1.21; 1.18 to 1.24), prematurity (1.09; 1.04 to 1.14), increasing reliever prescriptions (1.04; 1.03 to 1.04), number of previous attacks (1.03; 1.02 to 1.04) and previous hospitalisation with wheeze (1.09; 1.05 to 1.14) were also associated with further attacks.Older age at presentation (RR 0.92; 0.91 to 0.93) and number of prescriptions for inhaled corticosteroids (0.96; 0.95 to 0.97) in the previous year were associated with lower risk for further attacks. CONCLUSIONS: Our findings can be used to aid clinical risk prediction for further attacks of wheeze in preschool children. |
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| ジャーナル名 | Archives of disease in childhood |
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| Pubmed追加日 | 2025/6/21 |
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| 投稿者 | Lo, David; Lawson, Claire; Broomfield, Jonathan; Gillies, Clare; Shabnam, Sharmin; Gaillard, Erol A; Pinnock, Hilary; Quint, Jennifer |
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| 組織名 | Respiratory Sciences, University of Leicester, Leicester, UK dkhl1@le.ac.uk.;Paediatric Respiratory Medicine, University Hospitals of Leicester NHS Trust,;Leicester, UK.;Cardiovascular Sciences, University of Leicester, Leicester, UK.;Respiratory Sciences, University of Leicester, Leicester, UK.;Population Health Sciences, University of Leicester, Leicester, UK.;The University of Edinburgh Usher Institute of Population Health Sciences and;Informatics, Edinburgh, UK.;School of Public Health, Imperial College London, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40541289/ |
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