| アブストラクト | Apixaban and rivaroxaban are two agents commonly used for anticoagulation to treat and prevent blood clots and strokes in individuals with atrial fibrillation (AF). We extracted data from the FDA Adverse Event Reporting System (FAERS) database to evaluate the reporting frequency of ocular, cerebral, gastrointestinal (GI), rectal, and renal hemorrhage, epistaxis, and hemoptysis related to apixaban and rivaroxaban from January 2012 to March 2024. We calculated relative odds ratios (RORs) with 95% confidence intervals (CIs) to compare the hemorrhagic risk profiles of the two agents. There was no statistical significance in reported cases of ocular hemorrhage in apixaban versus rivaroxaban. Based on RORs, rivaroxaban overall has a significantly higher risk of bleeding in multiple organ systems - especially cerebral, GI, rectal, and renal hemorrhage, as well as epistaxis and hemoptysis. Apixaban may be a safer option for individuals at risk for, or with a history of, these complications. |
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| ジャーナル名 | Cureus |
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| Pubmed追加日 | 2025/7/8 |
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| 投稿者 | Logvinsky, Ilana K; Sanchez, Christian; Ciuciureanu, Claudiu; Wu, Eric; El Aryan, Osama; Delibasic, Maja |
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| 組織名 | Internal Medicine, Florida State University College of Medicine, Cape Coral, USA.;Internal Medicine, Nova Southeastern University, Miami, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40625517/ |
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