| アブストラクト | BACKGROUND: Heart failure (HF) is a global health issue with a high prevalence in aging populations. Sodium-glucose cotransporter-2 (SGLT2) inhibitors reduce HF-related hospitalizations and mortality; however, their adverse drug events (ADEs) require further evaluation. RESEARCH DESIGN AND METHODS: Using the Japan Medical Data Center and Japanese Adverse Drug Event Report (JADER) databases, we analyzed prescribing trends and ADE risk factors. Multivariate logistic regression assessed associations between patient characteristics and ADEs, adjusting for age, sex, medication use, and comorbidities. Decision tree analyses stratified ADE risks. RESULTS: SGLT2 inhibitor prescriptions increased from 1.63% (2018) to 9.08% (2022), with a notable rise in 2021. JADER analysis showed an increasing number of ADE reports, primarily dehydration, urinary tract infections, and renal impairment. Decision tree analyses identified risk factors: dehydration (age >/=80 years, tolvaptan use), urinary tract infection (female sex, renal dysfunction), and renal impairment (angiotensin receptor-neprilysin inhibitor use, history of renal dysfunction). CONCLUSIONS: Personalized risk assessment and monitoring are crucial for optimizing SGLT2 inhibitor therapy, particularly in older patients with HF and renal impairment. |
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| ジャーナル名 | Expert opinion on drug safety |
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| Pubmed追加日 | 2025/7/25 |
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| 投稿者 | Sato, Kazuya; Kawada, Kei; Ishida, Tomoaki; Kubo, Toru; Koji, Miyata; Aizawa, Fuka; Yagi, Kenta; Izawa-Ishizawa, Yuki; Niimura, Takahiro; Goda, Mitsuhiro; Ishizawa, Keisuke |
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| 組織名 | Department of Clinical Pharmacology and Therapeutics, Tokushima University;Graduate School of Biomedical Sciences, Tokushima, Japan.;Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.;Department of Pharmacy, Kochi Medical School Hospital, Kochi, Japan.;Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University,;Kochi, Japan.;Clinical Research Center for Developmental Therapeutics, Tokushima University;Hospital, Tokushima, Japan.;Department of General Medicine, Taoka Hospital, Tokushima, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40711847/ |
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